Signaling for NKT cell development: the SAP-FynT connection
Signaling for NKT cell development: the SAP-FynT connection
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DOI：
10.1084/jem.20050339
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发表时间：
2005-03-21
影响因子：
15.3
通讯作者：
Bendelac, A
中科院分区：
文献类型：
--
作者：
Borowski, C;Bendelac, A
新的研究表明，适配蛋白SAP(SLAM相关蛋白)在NKT细胞发育过程中起着关键作用。通过将同型SLAM家族受体与FynT Src激酶联系起来，SAP可能整合了一组长期存在但似乎完全不同的NKT细胞发育观察。事实上，SAP依赖的信号可能是多种非传统T细胞系发展的基础，这些T细胞系的胸腺选择依赖于造血细胞之间的同型相互作用。
New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src kinase, SAP may integrate a set of long-standing yet seemingly disparate observations characterizing NKT cell development. In fact, SAP-dependent signaling may underlie the development of multiple unconventional T cell lineages whose thymic selection relies on homotypic interactions between hematopoietic cells.