Expression of anglerfish preprosomatostatin genes in mammalian cells: studies on the synthesis and post-translational processing of somatostatin precursors.
Expression of anglerfish preprosomatostatin genes in mammalian cells: studies on the synthesis and post-translational processing of somatostatin precursors.
复制标题
鮟鱇鱼前生长抑素基因在哺乳动物细胞中的表达：生长抑素前体的合成和翻译后加工研究。
DOI：
10.1007/978-1-4615-7886-4_1
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发表时间：
1985
影响因子：
--
通讯作者：
Green,RF
中科院分区：
文献类型：
--
作者：
Shields,D;Warren,TG;Green,RF
生长抑素（SS）的主要形式是一种14个氨基酸的肽（SS-14，SRIF），其抑制包括生长激素、胰岛素和胰高血糖素在内的其它肽类激素的分泌。它在包括脑、下丘脑和胰岛在内的多种组织中合成，其氨基酸序列在大多数物种中高度保守（1）。生物合成研究（2，3）已经证明存在另一种生长抑素SS-28，它是在氨基末端含有额外14个氨基酸的SS-14;这种肽也直接从几种组织中分离出来（4-7）。现在已经确定，SS-14是作为更大的前体前生长抑制素（prepro-SS）的一部分合成的，前生长抑制素（prepro-SS）大约是成熟激素的八倍（8）。
The major form of somatostatin (SS) is a 14 amino acid peptide (SS-14, SRIF) that inhibits the secretion of other peptide hormones including growth hormone, insulin and glucagon. It is synthesized in several tissues including brain, hypothalamus and pancreatic islets and its amino acid sequence is highly conserved in most species (1). Biosynthetic studies (2, 3) have demonstrated the existence of another somatostatin, SS-28, which is the SS-14 containing an additional 14 amino acids localized at the amino terminus; this peptide has also been isolated directly from several tissues (4–7). It is now well established that SS-14 is synthesized as part of a larger precursor, preprosomatostatin (prepro-SS), which is about eight times larger than the mature hormone (8).