IL-27, a heterodimeric cytokine composed of EB13 and p28 protein, induces proliferation of naive CD4+ T cells
IL-27, a heterodimeric cytokine composed of EB13 and p28 protein, induces proliferation of naive CD4+ T cells
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DOI：
10.1016/s1074-7613(02)00324-2
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发表时间：
2002-06-01
期刊：
影响因子：
32.4
通讯作者：
Kastelein, RA
中科院分区：
文献类型：
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作者：
Pflanz, S;Timans, JC;Kastelein, RA
有效的Th1驱动的适应性免疫反应需要激活T细胞受体，并由激活的抗原提呈细胞分泌T细胞刺激细胞因子IL-12。IL-12可激活初始CD4(+)T细胞的Th1极化和干扰素-γ的分泌。我们描述了一种新的异二聚体细胞因子IL-27，它由IL-12p40相关蛋白EBI3和新发现的IL-12p35相关多肽p28组成。IL-27是活化的抗原提呈细胞的早期产物，推动幼稚但不具有记忆性的CD4+T细胞的快速克隆性增殖。它还与IL-12强烈协同作用，触发初始CD4(+)T细胞产生干扰素-伽马。IL-27通过孤儿细胞因子受体WSX-1/TCCR介导其生物学效应。
An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed IL-27 that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4+ T cells. It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR.