Synthesis of N-Substituted Sulfamate Esters from Sulfamic Acid Salts by Activation with Triphenylphosphine Ditriflate
Synthesis of N-Substituted Sulfamate Esters from Sulfamic Acid Salts by Activation with Triphenylphosphine Ditriflate
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DOI：
10.1021/acs.orglett.7b03059
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发表时间：
2017-11-03
期刊：
影响因子：
5.2
通讯作者：
Roizen, Jennifer L.
中科院分区：
文献类型：
--
作者：
Blackburn, J. Miles;Short, Melanie A.;Roizen, Jennifer L.
本发明公开了一种通过制备磺胺酸盐、随后用三苯基膦二甲基化活化和亲核捕获来获得磺胺酸酯的一般方法。该方法以中等到极好的产率纳入由脂肪醇和酚衍生的亲核试剂。该方法可用于制备差异取代磺胺。
A general approach to access sulfamate esters through preparation of sulfamic acid salts, subsequent activation with triphenylphosphine ditrifiate, and nudeophilic trapping is disclosed. The method proceeds in modest to excellent yields to incorporate nucleophiles derived from aliphatic alcohols and phenols. This approach can be employed to furnish differentially substituted sulfamides.