The inflammatory response in cerebral ischemia: Focus on cytokines in stroke patients
The inflammatory response in cerebral ischemia: Focus on cytokines in stroke patients
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DOI：
10.1081/ceh-120015330
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发表时间：
2002-10-01
影响因子：
12.3
通讯作者：
Gallai, V
中科院分区：
文献类型：
--
作者：
De Simoni, MG;Milia, P;Gallai, V
本文概述了脑缺血炎症反应的特点，目的是揭示其在脑缺血发病机制中的相关性和特异性含义。注意力集中在细胞因子，主要炎症介质产生在中枢神经系统和外周在脑损伤反应的背景下。本文回顾了脑卒中患者细胞因子的现有数据，以研究人类样本中炎症反应的特征，并阐明这些炎症分子的产生是否与临床结果有关。
This paper outlines the characteristics of the inflammatory reaction to brain ischemia with the aim of underlying its relevance and specific implication in the pathogenesis of this disorder. The attention is focused on cytokines, major inflammatory mediators produced in the central nervous system and in the periphery in the context of the response to brain injury. The available data on cytokines in patients with stroke are reviewed to investigate the characteristics of the inflammatory response in human samples and to elucidate if the production of these inflammatory molecules may be related to the clinical outcome.