Emergence of a peak in early infant mortality due to HIV/AIDS in South Africa
Emergence of a peak in early infant mortality due to HIV/AIDS in South Africa
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DOI：
10.1097/qad.0b013e32831c54bd
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发表时间：
2009-01-02
期刊：
影响因子：
3.8
通讯作者：
Myers, Jonny E.
中科院分区：
文献类型：
--
作者：
Bourne, David E.;Thompson, MaryLou;Myers, Jonny E.
目标：南非是世界上艾滋病毒流行率最高的国家之一。我们的目标是详细描述南非婴儿和儿童死亡率按年龄的分布，确定最近的任何趋势，并检查这些趋势与艾滋病毒相关和非艾滋病毒相关的死亡原因。方法：对生命登记数据进行回顾。对南非1997-2002年间登记在册的1岁以下新生儿死亡病例按月按年龄进行分析。结果：1997-2002年间，南非新生儿后死亡率逐年上升。观察到艾滋病毒相关死亡的高峰，集中在2-3个月大，随着时间的推移单调上升。结论：我们将2-3个月的死亡率峰值解释为在艾滋病毒流行率较高且其他死因不足以掩盖艾滋病毒影响的南非人口中的儿科艾滋病的指标。宫内和产中感染可能是导致这一高峰的原因之一。它可能是一个有用的监视工具，不需要确切的死因。研究结果还表明，在艾滋病毒流行率非常高的环境中，有必要对母亲和儿童进行早期治疗。(C)2009年Wolters Kluwer Health垂直酒吧Lippincott Williams&Wilkins
Objectives: South Africa has among the highest levels of HIV prevalence ill the world. Our objectives are to describe the distribution of South African infant and child mortality by age at fine resolution, to identify any trends over recent time and to examine these trends for HIV-associated and non HIV-associated causes of mortality.Methods: A retrospective review of vital registration data was conducted. All registered postneonatal deaths under 1 year of age in South Africa for the period 1997-2002 were analysed by age in months using a generalized linear model with a log link and Poisson family.Results: Postneonatal mortality increased each year over the period 1997-2002. A peak in HIV-related deaths was observed, centred at 2-3 months of age, rising monotonically over time.Conclusion: We interpret the peak in mortality at 2-3 months as an indicator for paediatric AIDS in a South African population with high HIV prevalence and where other Causes of death are not sufficiently high to mask HIV effects. Intrauterine and intrapartum infection may contribute to this peak. It is potentially a useful Surveillance tool, not requiring an exact cause of death. The findings also illustrate the need for early treatment of mother and child in settings with very high HIV prevalence. (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins