A COMPARISON OF POSITIVE FAMILY HISTORY DEFINITIONS FOR DEFINING RISK OF FUTURE DISEASE
A COMPARISON OF POSITIVE FAMILY HISTORY DEFINITIONS FOR DEFINING RISK OF FUTURE DISEASE
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DOI：
10.1016/0021-9681(86)90083-4
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发表时间：
1986-01-01
期刊：
影响因子：
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通讯作者：
BARLOW, GK
中科院分区：
文献类型：
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作者：
HUNT, SC;WILLIAMS, RR;BARLOW, GK
对94，292人的寿命表数据应用阳性和阴性家族史的不同定义，比较了阳性和阴性家族史家族之间未来发生冠心病（CHD）或高血压的相对风险。有两个或两个以上的一级亲属患有CHD，表明8%的人群在50岁之前患CHD的相对风险为3.3-5.9。定量家族史评分（FHS）将家族的年龄和性别特异性疾病发病率与一般人群的预期发病率进行比较，并预测未受影响的家族成员未来的疾病发病率略好（50岁之前CHD的相对风险=3.4-6.9）。仅使用一个受影响的亲属，即使在很小的时候就受影响（
The relative risk of developing future coronary heart disease (CHD) or hypertension between positive and negative family history families is compared for different definitions of a positive family history when applied to life-table data for 94,292 persons. Having two or more first degree relatives with CHD identifies 8% of the population with relative risks of 3.3-5.9 for CHD before age 50. A quantitative family history score (FHS) compares the family''s age and sex specific disease incidence to that expected in the general population and predicts future disease incidence in unaffected family members slightly better (relative risks=3.4-6.9 for CHD before age 50). Using only one affected relative, even if affected at an early age (