Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development
Recent advances and potential applications of modulated differential scanning calorimetry (mDSC) in drug development
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DOI：
10.1016/j.ejps.2015.12.024
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发表时间：
2016-05-25
影响因子：
4.6
通讯作者：
Holm, Rene
中科院分区：
文献类型：
--
作者：
Knopp, Matthias Manne;Lobmann, Korbinian;Holm, Rene
差示扫描量热法（DSC）经常是预配制和配方科学中选择的热分析技术，因为其能够提供关于物质和/或配方的物理和能量性质的详细信息。然而，常规DSC具有关于弱跃迁和重叠事件的缺点，这可以通过使用更复杂的调制DSC（mDSC）来解决。mDSC在制药领域有多种潜在的应用，本综述提供了这些应用的最新概述。它的目的是作为一个广泛的介绍新人，也作为一个宝贵的参考那些已经在外地执业。复合mDSC在二十多年前被引入，并且一直是定量无定形材料和开发冻干制剂的重要工具。然而，正如本综述中所讨论的，许多其他潜在的应用也可能与制药科学家有关。(C)2015爱思唯尔B. V.保留所有权利。
Differential scanning calorimetry (DSC) is frequently the thermal analysis technique of choice within preformulation and formulation sciences because of its ability to provide detailed information about both the physical and energetic properties of a substance and/or formulation. However, conventional DSC has shortcomings with respect to weak transitions and overlapping events, which could be solved by the use of the more sophisticated modulated DSC (mDSC). mDSC has multiple potential applications within the pharmaceutical field and the present review provides an up-to-date overview of these applications. It is aimed to serve as a broad introduction to newcomers, and also as a valuable reference for those already practising in the field. Complex mDSC was introduced more than two decades ago and has been an important tool for the quantification of amorphous materials and development of freeze-dried formulations. However, as discussed in the present review, a number of other potential applications could also be relevant for the pharmaceutical scientist. (C) 2015 Elsevier B.V. All rights reserved.