Photon-tissue interaction model enables quantitative optical analysis of human pancreatic tissues.
Photon-tissue interaction model enables quantitative optical analysis of human pancreatic tissues.
复制标题
DOI：
10.1364/oe.18.021612
复制
发表时间：
2010-10-11
期刊：
影响因子：
3.8
通讯作者：
Mycek MA
中科院分区：
文献类型：
--
作者：
Wilson RH;Chandra M;Chen LC;Lloyd WR;Scheiman J;Simeone D;Purdy J;McKenna B;Mycek MA
开发了光子组织相互作用 (PTI) 模型，并用于分析来自新鲜切除的人胰腺组织的 96 对反射和荧光光谱。对于每对光谱，PTI 模型从测量的反射率中提取细胞核尺寸参数，以及细胞外和细胞内荧光团对内在荧光的相对贡献。结果表明，反射光谱和荧光光谱有可能定量区分胰腺组织类型，包括正常胰腺组织、胰腺炎和胰腺腺癌。
A photon-tissue interaction (PTI) model was developed and employed to analyze 96 pairs of reflectance and fluorescence spectra from freshly excised human pancreatic tissues. For each pair of spectra, the PTI model extracted a cellular nuclear size parameter from the measured reflectance, and the relative contributions of extracellular and intracellular fluorophores to the intrinsic fluorescence. The results suggest that reflectance and fluorescence spectroscopies have the potential to quantitatively distinguish among pancreatic tissue types, including normal pancreatic tissue, pancreatitis, and pancreatic adenocarcinoma.