The mechanical and material properties of elderly human articular cartilage subject to impact and slow loading
The mechanical and material properties of elderly human articular cartilage subject to impact and slow loading
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DOI：
10.1016/j.medengphy.2013.11.002
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发表时间：
2014-02-01
影响因子：
2.2
通讯作者：
Aspden, R. M.
中科院分区：
文献类型：
--
作者：
Burgin, L. V.;Edelsten, L.;Aspden, R. M.
关节软骨的机械性能随负荷率变化很大，并且这些性能如何从组织的组成和结构中得出仍不清楚。这项研究研究了人类关节软骨在快速加载速率下的机械特性，将这些特性与慢速加载下的测量结果进行比较，并探讨它们与组织总体成分的关系。对全深度股骨头软骨活检进行缓慢、无侧限压缩测试，然后进行能量为 78.5 rnJ、速度为 1.25 m s(-1) 的冲击。根据加载曲线的斜率以及加载和卸载曲线下面积的恢复系数计算模量。组织成分测量为水、胶原蛋白和糖胺聚糖含量。最大动态模量范围为25至150 MPa。这些值与准静态加载期间测得的 1-3 MPa 进行比较。恢复系数为 0.502 (0.066)（平均值（标准差）），并且没有显示位点变异。未检测到失水。成分与模量没有很强的相关性；水和胶原蛋白含量共同预测了大约 25% 的模量变化。 (C) 2013 年 IPEM。由爱思唯尔有限公司出版。保留所有权利。
The mechanical properties of articular cartilage vary enormously with loading rate, and how these properties derive from the composition and structure of the tissue is still unclear. This study investigates the mechanical properties of human articular cartilage at rapid rates of loading, compares these with measurements at slow rates of loading and explores how they relate to the gross composition of the tissue. Full-depth femoral head cartilage biopsies were subjected to a slow, unconfined compression test followed by an impact at an energy of 78.5 rnJ and velocity 1.25 m s(-1). The modulus was calculated from the slope of the loading curve and the coefficient of restitution from the areas under the loading and unloading curves.Tissue composition was measured as water, collagen and glycosaminoglycan contents. The maximum dynamic modulus ranged from 25 to 150 MPa. These values compared with 1-3 MPa measured during quasi-static loading. The coefficient of restitution was 0.502 (0.066) (mean (standard deviation)) and showed no site variation. Water loss was not detectable. Composition was not strongly associated with modulus; water and collagen contents together predicted about 25% of the variance in modulus. (C) 2013 IPEM. Published by Elsevier Ltd. All rights reserved.