Growth hormone pulsatility profile characteristics following acute heavy resistance exercise.
Growth hormone pulsatility profile characteristics following acute heavy resistance exercise.
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急性重阻力运动后生长激素搏动曲线特征。
DOI：
10.1152/jappl.2001.91.1.163
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Kraemer,WJ
中科院分区：
文献类型：
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作者：
Nindl,BC;Hymer,WC;Deaver,DR;Kraemer,WJ
本研究检验了急性重阻力运动（AHRE）会增加循环人生长激素（hGH）过夜浓度的假设。10名男性（22 ± 1岁，177 ± 2 cm，79 ± 3 kg，11 ± 1%体脂）从17：00至06：00每10分钟进行两次过夜采血：对照和AHRE条件。AHRE于1500点至1700点进行，是一场大容量、多组运动比赛。三种不同的免疫测定法测量hGH浓度：Nichols免疫放射测定法（Nichols IRMA）、国家糖尿病、消化和肾脏疾病研究所放射免疫测定法（NIDDK RIA）和诊断系统实验室免疫功能测定法（DSL IFA）。使用Pulsar峰值检测系统评价hGH的脉动曲线特征。运动条件下的最大hGH（10.7 μ g/l）低于对照条件下的最大hGH（15.4 μ g/l）。当通过Nichols IRMA和DSL IFA测量时，运动与对照条件下的平均脉搏幅度较低。运动后还观察到不同的释放模式，其中hGH在睡眠的前半部分较低，但在后半部分较高。我们的结论是AHRE确实影响夜间hGH脉动的时间模式。此外，由于DSL IFA的独特分子基础，这种影响确实具有生物学相关性，因为功能完整的分子受到影响。
This investigation examined the hypothesis that acute heavy resistance exercise (AHRE) would increase overnight concentrations of circulating human growth hormone (hGH). Ten men (22 ± 1 yr, 177 ± 2 cm, 79 ± 3 kg, 11 ± 1% body fat) underwent two overnight blood draws sampled every 10 min from 1700 to 0600: a control and an AHRE condition. The AHRE was conducted from 1500 to 1700 and was a high-volume, multiset exercise bout. Three different immunoassays measured hGH concentrations: the Nichols immunoradiometric assay (Nichols IRMA), National Institute of Diabetes and Digestive and Kidney Diseases radioimmunoassay (NIDDK RIA), and the Diagnostic Systems Laboratory immunofunctional assay (DSL IFA). The Pulsar peak detection system was used to evaluate the pulsatility profile characteristics of hGH. Maximum hGH was lower in the exercise (10.7 μg/l) vs. the control (15.4 μg/l) condition. Mean pulse amplitude was lower in the exercise vs. control condition when measured by the Nichols IRMA and the DSL IFA. A differential pattern of release was also observed after exercise in which hGH was lower in the first half of sleep but higher in the second half. We conclude that AHRE does influence the temporal pattern of overnight hGH pulsatility. Additionally, because of the unique molecular basis of the DSL IFA, this influence does have biological relevance because functionally intact molecules are affected.