Human Scleral Structural Stiffness Increases More Rapidly With Age in Donors of African Descent Compared to Donors of European Descent
Human Scleral Structural Stiffness Increases More Rapidly With Age in Donors of African Descent Compared to Donors of European Descent
复制标题
DOI：
10.1167/iovs.14-14894
复制
发表时间：
2014-11-01
影响因子：
4.4
通讯作者：
Downs, J. Crawford
中科院分区：
文献类型：
--
作者：
Fazio, Massimo A.;Grytz, Rafael;Downs, J. Crawford
目的.我们检验了一个假设，即欧洲（艾德）和非洲（AD）血统的供体的视乳头周围巩膜结构刚度随年龄的变化是不同的。在死后48小时内，对来自0岁和90岁的欧洲人（n = 20对;先前报道）和非洲人（n = 9对）后裔的供体的正常眼睛的后巩膜壳进行膨胀测试。将巩膜壳加压至5至45 mm Hg，并使用散斑干涉术（ESPI）以亚微米精度记录外表面的全场三维（3D）变形。平均最大主（拉伸）应变的视乳头周围和中周边区域周围的视神经乳头（ONH）进行了拟合使用功能混合效应模型，占供体内的变异性，同种族相关性，和空间自相关性估计种族对年龄相关的机械巩膜应变变化的影响。在非洲和欧洲血统组中，视乳头周围巩膜的机械拉伸应变随年龄的增长而显著降低（P < 0.001），但非洲血统组中与年龄相关的硬化程度显著更大（P < 0.05）。在两个种族组中，视乳头周围巩膜的最大主应变显著高于中周边巩膜。与欧洲人组相比，非裔组ONH周围的巩膜随着年龄的增长而更快地变硬。随着年龄的增长，视乳头周围巩膜变硬可能与老年人和非洲裔人青光眼的发病率较高有关。
PURPOSE. We tested the hypothesis that the variation of peripapillary scleral structural stiffness with age is different in donors of European (ED) and African (AD) descent.METHODS. Posterior scleral shells from normal eyes from donors of European (n = 20 pairs; previously reported) and African (n = 9 pairs) descent aged 0 and 90 years old were inflation tested within 48 hours post mortem. Scleral shells were pressurized from 5 to 45 mm Hg and the full-field, 3-dimensional (3D) deformation of the outer surface was recorded at submicrometric accuracy using speckle interferometry (ESPI). Mean maximum principal (tensile) strain of the peripapillary and midperipheral regions surrounding the optic nerve head (ONH) were fit using a functional mixed effects model that accounts for intradonor variability, same-race correlation, and spatial autocorrelation to estimate the effect of race on the age-related changes in mechanical scleral strain.RESULTS. Mechanical tensile strain significantly decreased with age in the peripapillary sclera in the African and European descent groups (P < 0.001), but the age-related stiffening was significantly greater in the African descent group (P < 0.05). Maximum principal strain in the peripapillary sclera was significantly higher than in the midperipheral sclera for both ethnic groups.CONCLUSIONS. The sclera surrounding the ONH stiffens more rapidly with age in the African descent group compared to the European group. Stiffening of the peripapillary sclera with age may be related to the higher prevalence of glaucoma in the elderly and persons of African descent.