The parametric response map is an imaging biomarker for early cancer treatment outcome.
The parametric response map is an imaging biomarker for early cancer treatment outcome.
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在这里，我们描述了参数响应图（PRM），一个逐体素的方法，用于图像分析和定量血流动力学的改变，在治疗44例高级别胶质瘤患者。在治疗前和治疗后1周和3周获得相对脑血容量（rCBV）和流量（rCBF）图。我们比较了标准的方法，使用区域的兴趣分析的变化，rCBV或rCBF的灌注参数的变化的基础上，PRM（PRMrCBV和PRMrCBF）的准确性预测总生存期。rCBV或rCBF的百分比变化均不能预测生存率，而基于PRM的区域反应评估对生存率具有高度预测性。即使考虑到基线rCBV，这是预后，PRMrCBV被证明更能预测总生存期。
Here we describe the Parametric Response Map (PRM), a voxel-wise approach for image analysis and quantification of hemodynamic alterations during treatment for 44 patients with high-grade glioma. Relative cerebral blood volume (rCBV) and flow (rCBF) maps were acquired before treatment and after 1 and 3 weeks of therapy. We compared the standard approach using region-of-interest analysis for change in rCBV or rCBF to the change in perfusion parameters on the basis of PRM (PRMrCBV and PRMrCBF) for their accuracy in predicting overall survival. Neither the percentage change of rCBV or rCBF predicted survival, whereas the regional response evaluations based upon PRM were highly predictive of survival. Even when accounting for baseline rCBV, which is prognostic, PRMrCBV proved more predictive of overall survival.
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Moffat, Bradford A.;Chenevert, Thomas L.;Ross, Brian D.
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