A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer.
A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer.
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DOI：
10.4238/gmr.15017486
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发表时间：
2016-02
期刊：
影响因子：
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通讯作者：
Xin Huang;Yuqiu Yang;Cui Zw;J. Wang;Linbo Gao
中科院分区：
文献类型：
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作者：
Xin Huang;Yuqiu Yang;Cui Zw;J. Wang;Linbo Gao
The insertion/deletion polymorphism (rs3783553 TTCA/-) in the 3' untranslated region of interleukin-1A (IL1A) has been studied intensively and has been shown to affect tumor risk. We studied the frequency of the IL1A gene polymorphism rs3783553 and evaluated its relationship with breast cancer (BC). A hospital-based case-control study comprising 228 patients with histologically confirmed BC and 241 healthy subjects was conducted. Polymerase chain reaction was used to detect the IL1A rs3783553 polymorphism. The ins/ins (ttca/ttca) genotype was significantly associated with a decreased risk of BC compared with the del/del (-/-) genotype (OR = 0.48, 95% CI = 0.27-0.85). Moreover, the ins (ttca) allele distribution between cases and controls was significantly different from the del (-) allele distribution (OR = 0.74, 95% CI = 0.57-0.96). Thus, the rs3783553 polymorphism is associated with a decreased incidence of breast cancer.
