Air pollution - A new risk factor in ischemic stroke mortality
Air pollution - A new risk factor in ischemic stroke mortality
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DOI：
10.1161/01.str.0000026865.52610.5b
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发表时间：
2002-09-01
期刊：
影响因子：
8.3
通讯作者：
Kwon, HJ
中科院分区：
文献类型：
--
作者：
Hong, YC;Lee, JT;Kwon, HJ
背景和目的-空气污染与心血管疾病有关，但对与空气污染有关的中风的发生知之甚少。我们在韩国首尔调查了7年间(1991年1月至1997年12月)急性中风死亡率和空气污染之间的关系。方法-采用广义加性模型回归每种空气污染物的每日中风死亡人数，控制时间趋势、星期几和气象影响，如温度、相对湿度和大气压力，分别检查缺血性中风和出血性中风死亡人数。结果-空气污染物对缺血性中风死亡率的影响在统计学上显著，而出血性中风则不是这样死亡率我们观察到每个四分位数范围内缺血性中风死亡率的估计相对风险分别为103(95%可信区间1 00至1 06)和104(95%可信区间1 01至1 08)。在同一天，总悬浮颗粒物和二氧化硫浓度的增加也发现二氧化氮的相对风险显著增加104(95%可信区间101至107)，一氧化碳1天滞后106(95%可信区间1 02至1 09)，臭氧每四分位区间滞后3天的相对风险增加106(95%可信区间1 02至110结论--这些发现表明空气污染物与缺血性卒中死亡率显著相关，提示空气污染导致脑血管系统的急性致病过程。
Background and Purpose-Air pollution is known to be associated with cardiovascular disease but little is known about the occurrence of stroke in relation to air pollution We investigated the association between acute stroke mortality and air pollution over a 7 year period (January 1991 through December 1997) in Seoul KoreaMethods-A generalized additive model was used to regress daily stroke death counts for each air pollutant controlling for time trends day of the week and meteorological influences such as temperature relative humidity and atmospheric pressure Ischemic and hemorrhagic stroke deaths were examined separatelyResults-The effects of air pollutants on ischemic stroke mortality were statistically significant whereas this was not the case for hemorrhagic stroke mortality We observed estimated relative risks of 103 (95% CI 1 00 to 1 06) and 104 (95% CI 1 01 to 1 08) for ischemic stroke mortality for each interquartile range increase in total suspended particulates and sulfur dioxide concentrations on the same day We also found significantly increased relative risks of 104 (95% CI 101 to 107) for nitrogen dioxide with a 1 day lag of 106 (95% CI 1 02 to 1 09) for carbon monoxide with a I day lag and of 106 (95% CI 1 02 to 1 10) for ozone with a 3 day lag for each interquartile range increaseConclusions-These findings indicate that air pollutants are significantly associated with ischemic stroke mortality which suggests an acute pathogenetic process in the cerebrovascular system induced by air pollution.