Early-Childhood Social Reticence Predicts Brain Function in Preadolescent Youths During Distinct Forms of Peer Evaluation.
Early-Childhood Social Reticence Predicts Brain Function in Preadolescent Youths During Distinct Forms of Peer Evaluation.
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DOI：
10.1177/0956797616638319
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发表时间：
2016-06
影响因子：
8.2
通讯作者：
Nelson EE
中科院分区：
文献类型：
--
作者：
Jarcho JM;Davis MM;Shechner T;Degnan KA;Henderson HA;Stoddard J;Fox NA;Leibenluft E;Pine DS;Nelson EE
Social reticence (SR) manifests as shy, anxiously avoidant behavior in early childhood. With development, overt signs of SR may diminish but could still manifest in neural responses to peers. Measures of SR were obtained across ages 2-to-7 years. At age 11, pre-adolescents previously characterized as high (N=30) or low (N=23) in SR completed a novel fMRI-based peer interaction task that quantifies neural responses to the anticipation and receipt of distinct forms of social evaluation. While anticipating unpredictable compared with predictable feedback, high relative to low childhood SR was associated with greater activity in dorsal anterior cingulate and bilateral insula, brain regions implicated in processing salience and distress. High SR was also associated with negative functional connectivity between insula and ventromedial prefrontal cortex, a region commonly implicated in affect regulation. Finally, among the high SR group, negative evaluation was associated with increased amygdala activity, but only during feedback from unpredictable peers.
