SUMOrganization of the nucleus
SUMOrganization of the nucleus
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DOI：
10.1016/j.ceb.2007.04.014
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发表时间：
2007-06-01
影响因子：
7.5
通讯作者：
Heun, Patrick
中科院分区：
文献类型：
--
作者：
Heun, Patrick
在真核细胞核中，基因表达和基因组完整性的维持在多个水平上受到严格控制，从分子细节到基因组的高级结构。细胞核包含空间上和功能上不同的区室，这些基本过程在其中进行。虽然一些核子域的动力学和功能，如核仁，已经得到了很好的研究，其他领域，如PML核体，仍然是谜。最近的证据表明SUMO化途径在亚核结构中起着重要作用，特别是在PML核体的组装中。相关功能包括染色质环的组织和rDNA重复序列稳定性的维持。因此，SUMO修饰的完全丧失深刻地影响核组织和细胞活力。
In the eukaryotic nucleus, gene expression and maintenance of genome integrity are tightly controlled at multiple levels, from the molecular details to the higher-order structure of the genome. The nucleus contains spatially and functionally distinct compartments in which these fundamental processes are carried out. While the dynamics and functions of some nuclear subdomains, like the nucleolus, have been well studied, other domains, like the PML-nuclear bodies, remain enigmatic. Recent evidence has now implicated the SUMOylation pathway as an important player in subnuclear architecture, particularly in the assembly of PML-nuclear bodies. Related functions include the organization of chromatin loops and maintenance of rDNA repeat stability. Consequently, complete loss of SUMO modification profoundly affects nuclear organization and cell viability.