RAT COLD WATER TAIL-FLICK - A NOVEL ANALGESIC TEST THAT DISTINGUISHES OPIOID AGONISTS FROM MIXED AGONIST-ANTAGONISTS
RAT COLD WATER TAIL-FLICK - A NOVEL ANALGESIC TEST THAT DISTINGUISHES OPIOID AGONISTS FROM MIXED AGONIST-ANTAGONISTS
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DOI：
10.1016/0014-2999(85)90317-6
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发表时间：
1985-12-10
影响因子：
5
通讯作者：
ADLER, MW
中科院分区：
文献类型：
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作者：
PIZZIKETTI, RJ;PRESSMAN, NS;ADLER, MW
目前用于评估动物抗伤害功效的模型远非理想。除非调整有害刺激，否则那些检测阿片类激动剂和混合激动剂-拮抗剂的程序无法区分它们。此外，测试灵敏度的变化通常会导致从不是镇痛药或充其量只是弱镇痛药的药物中引发阳性反应。本报告中描述的技术使用冷水作为大鼠的有害刺激物。它很简单，不需要复杂的仪器或培训，与人类的临床疗效密切相关，并且可以将阿片类激动剂与混合激动剂-拮抗剂分离，而无需检测非阿片类药物。
The models currently used to assess antinociceptive efficacy in animals are far from ideal. Those procedures that detect both opioid agonists and mixed agonist-antagonists fail to differentiate between them unless the noxious stimulus is adjusted. Furthermore, changes in the sensitivity of the test often result in positive responses being elicited from agents that are either not analgesics or only weak ones, at best. The technique described in this report uses cold water as the noxious stimulus in rats. It is simple, requires no complicated instrumentation or training, correlates well with clinical efficacy in man, and allows separation of opioid agonists from mixed agonist-antagonists without detecting non-opioid agents.