Gut microbiota-brain interaction: An emerging immunotherapy for traumatic brain injury.
Gut microbiota-brain interaction: An emerging immunotherapy for traumatic brain injury.
复制标题
肠道微生物群-大脑相互作用：一种新兴的创伤性脑损伤免疫疗法。
DOI：
10.1016/j.expneurol.2020.113585
复制
发表时间：
2021
影响因子：
5.3
通讯作者：
Yong Jiang
中科院分区：
文献类型：
--
作者：
Yuxuan Zhang;Zhaoyang Wang;Jianhua Peng;Stefan T. Gerner;Shigang Yin;Yong Jiang
遭受创伤性脑损伤（TBI）的个体通常会经历免疫系统的激活，导致脑损伤后认知和神经功能下降。尽管经过了几十年的努力，临床有效的治疗方法仍然很少。目前的治疗策略和TBI后的临床结果之间的关联的证据仅限于对机制的不了解。几十年来，越来越多的研究表明，肠脑轴（GBA）是中枢神经系统（CNS）和胃肠道之间的双向通信系统，在神经系统疾病后的全身免疫反应中起着关键作用。在这篇综述中，我们详细介绍了目前对TBI后GBA免疫病理的了解。这些过程可能为TBI患者的临床治疗提供新的治疗靶点和康复策略。
Individuals suffering from traumatic brain injury (TBI) often experience the activation of the immune system, resulting in declines in cognitive and neurological function after brain injury. Despite decades of efforts, approaches for clinically effective treatment are sparse. Evidence on the association between current therapeutic strategies and clinical outcomes after TBI is limited to poorly understood mechanisms. For decades, an increasing number of studies suggest that the gut-brain axis (GBA), a bidirectional communication system between the central nervous system (CNS) and the gastrointestinal tract, plays a critical role in systemic immune response following neurological diseases. In this review, we detail current knowledge of the immune pathologies of GBA after TBI. These processes may provide a new therapeutic target and rehabilitation strategy developed and used in clinical treatment of TBI patients.