The role of gap junctions and ion channels in the modulation of electrical and chemical signals in human corpus cavernosum smooth muscle.
The role of gap junctions and ion channels in the modulation of electrical and chemical signals in human corpus cavernosum smooth muscle.
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DOI：
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发表时间：
1993-06
影响因子：
2.6
通讯作者：
G. Christ;P. Brink;A. Melman;D. Spray
中科院分区：
文献类型：
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作者：
G. Christ;P. Brink;A. Melman;D. Spray
通过水性细胞间通道（称为间隙连接）进行的细胞间通讯被认为是人体阴茎勃起和消肿过程中协调阴茎体平滑肌快速同步反应的重要机制。利用药物扩散的数学建模分析来研究细胞间通路对人阴茎海绵体平滑肌张力调节的潜在生理重要性。此外，进行膜片钳分析和光学成像研究，以评估培养的阴茎海绵体平滑肌细胞的细胞兴奋性和稳态的离子基础。简而言之，计算机建模研究表明，通过间隙连接的细胞间通信可能是协调该组织中细胞活化和合胞体平滑肌反应的“首选”途径。此外，所观察到的离子通道多样性揭示了更进一步的复杂性，以调制的身体平滑肌张力。
Intercellular communication through aqueous intercellular channels, known as gap junctions, has been postulated to provide an important mechanism for coordinating the rapid and synchronous responses of corporal smooth muscle during human penile erection and detumescence. Mathematical modeling analyses of drug diffusion were utilized to examine the potential physiological importance of the intercellular pathway to the regulation of smooth muscle tone in the human corpus cavernosum. In addition, patch clamp analyses and optical imaging studies were conducted to assess the ionic basis for cellular excitability and homeostasis in cultured corporal smooth muscle cells. In short, the computer modeling studies demonstrated that intercellular communication through gap junctions is likely to be the 'preferred' pathway for coordination of cellular activation and syncytial smooth muscle responses in this tissue. Moreover, the observed ion channel diversity reveals even further complexities to the modulation of corporal smooth muscle tone.