Wheel running simultaneously induces CTA and facilitates feeding in non-deprived rats
Wheel running simultaneously induces CTA and facilitates feeding in non-deprived rats
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DOI：
10.1006/appe.1998.0171
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发表时间：
1998-12-01
期刊：
影响因子：
5.4
通讯作者：
Gaborko, LL
中科院分区：
文献类型：
--
作者：
Lett, BT;Grant, VL;Gaborko, LL
以前的研究结果表明，车轮运行可以有一个厌恶或食欲的影响。也就是说，车轮运行30分钟诱导条件性味觉厌恶（CTA）的大鼠训练，而饥饿和口渴，但有利于非剥夺大鼠喂养。在实验1中，还发现轮跑在非剥夺大鼠中有效地产生CTA。因此，实验2测试了轮跑是否同时产生了厌恶和食欲效应。在四次训练试验中，两组非剥夺大鼠给予调味溶液饮用10分钟，然后将车轮组的大鼠放入转轮中30分钟，而笼组的大鼠在小笼中30分钟。最后，对所有大鼠进行60 min喂养试验。在第一次试验后，在其余的每次试验中，轮组比笼组喝更少的调味溶液。在每次喂食试验中，轮子组也比笼子组吃得更多。这些结果表明，车轮运行产生CTA，并促进进食在同一时间。中脑边缘多巴胺奖励系统在这些影响中的作用被认为是。(C)北京：科学出版社.
Previous findings indicate that wheel running can have either an aversive or an appetitive effect. That is, wheel running for 30 min induces conditioned taste aversion (CTA) in rats trained while hungry and thirsty but facilitates feeding in non-deprived rats. In Experiment 1, wheel running was also found to be effective in producing CTA in non-deprived rats. Therefore, Experiment 2 tested whether wheel running produces the aversive and appetitive effects simultaneously. During each of four training trials, two groups of non-deprived rats were given a flavored solution to drink for 10 min. Then those in the wheel group were put in running wheels for 30 min whereas those in the cage group spent 30 min in small cages. Finally, all rats were given a 60-min feeding test. After the first trial, the wheel group drank less flavored solution than the cage group during each of the remaining trials. The wheel group also ate more than the cage group on each feeding test. These results indicate that wheel running produces CTA and facilitates eating at the same time. A role for the mesolimbic dopamine reward system in these effects was considered. (C) 1998 Academic Press.