Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration
Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration
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DOI：
10.1016/j.ajo.2006.11.041
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发表时间：
2007-03-01
影响因子：
4.2
通讯作者：
Schmitz-Valckenberg, Steffen
中科院分区：
文献类型：
--
作者：
Holz, Frank G.;Bindewald-Wittich, Almut;Schmitz-Valckenberg, Steffen
中心点目的：检测地理萎缩(GA)周围的眼底自发荧光(Faf)模式对萎缩性年龄相关性黄斑变性(AMD)患者随时间推移的GA进展率的影响。中心点设计：前瞻性纵向多中心自然史研究。中心点方法：使用共聚焦扫描激光眼底镜(激发波长488 nm，发射波长500 nm)获取129例(195只眼)地理萎缩患者的标准化数字Faf图像。对GA区域进行量化，并对交界区异常Faf的类型进行分类。中心点结果：GA的面积(基线时的中位数为7.04mm2；IQR为3.12~10.0)平均放大1.52 mm(2)/年(IQR为0.81~2.33)。带状(中位数1.81 mm(2)/年)和弥漫性Faf(1.77 mm(2)/年)的进展率显著高于无Faf异常的眼(0.38 mm(2)/年)和局灶性Faf(0.81 mm(2)/年，P
center dot PURPOSE: To test if fundus autofluorescence (FAF) patterns around geographic atrophy (GA) have an impact on GA progression rates over time in atrophic age,related macular degeneration (AMD).center dot DESIGN: Prospective longitudinal multicenter natural history study.center dot METHODS: Standardized digital FAF images were obtained from 195 eyes of 129 patients with GA using confocal scanning laser ophthalmoscopy (excitation 488 nm, emission > 500 nm). Areas of GA were quantified and patterns of abnormal FAF in the junctional zone were classified. Repeated FAF images were obtained over a median follow-up period of 1.80 years (interquartile range [IQR], 1.28 to 3.34).center dot RESULTS: Areas of GA (median, 7.04 mm 2 at baseline; IQR, 3.12 to 10.0) showed a median enlargement of 1.52 mm(2)/year (IQR, 0.81 to 2.33). Progression rates in eyes with the banded (median 1.81 mm(2)/year) and the diffuse FAF pattern (1.77 mm(2)/year) were significantly higher compared to eyes without FAF abnormalities (0.38 mm(2)/year) and focal FAF patterns (0.81 mm(2)/year, P