Human Pupillary Dilation Response to Deviant Auditory Stimuli: Effects of Stimulus Properties and Voluntary Attention.
Human Pupillary Dilation Response to Deviant Auditory Stimuli: Effects of Stimulus Properties and Voluntary Attention.
复制标题
人类瞳孔扩张对异常听觉刺激的反应：刺激特性和自愿注意的影响。
DOI：
10.3389/fnins.2016.00043
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发表时间：
2016
影响因子：
4.3
通讯作者：
Furukawa S
中科院分区：
文献类型：
--
作者：
Liao HI;Yoneya M;Kidani S;Kashino M;Furukawa S
偏离重复背景声音的独特声音会引起特征性神经反应，例如脑电图研究中的不匹配负性和新奇的 P3 反应。在这里，我们表明，异常的听觉刺激会引起人类瞳孔扩张反应（PDR），该反应对刺激特性敏感，无论注意力是否集中在声音上。在一个奇怪的听觉序列中，我们使用白噪声和 2000 Hz 音调来对抗重复的 1000 Hz 音调。参与者在聆听奇怪的听觉序列时的瞳孔反应被记录下来。在实验1中，他们没有参与任何任务。结果显示，对于噪音怪异，瞳孔会扩张约 4 秒，但对于 2000 Hz 音调怪异，没有发现这样的 PDR。在实验2中，两种视觉异常与听觉异常同步呈现。参与者区分听觉或视觉上的奇怪现象，同时试图忽略来自其他方式的刺激。这种操纵的目的是将注意力转移到或远离听觉序列。在实验3中，视觉怪人和听觉怪人总是异步呈现，以防止由于与被关注的怪人同时发生而将注意力残留在待忽略的怪人身上。结果表明，在所有条件下，在噪声和 2000 Hz 音调下，瞳孔都会放大。最重要的是，无论两个实验中的注意力条件如何，噪声的 PDR 都大于 2000 Hz 音调怪异的 PDR。总体结果表明，PDR 的刺激依赖性因素似乎与注意力无关。
A unique sound that deviates from a repetitive background sound induces signature neural responses, such as mismatch negativity and novelty P3 response in electro-encephalography studies. Here we show that a deviant auditory stimulus induces a human pupillary dilation response (PDR) that is sensitive to the stimulus properties and irrespective whether attention is directed to the sounds or not. In an auditory oddball sequence, we used white noise and 2000-Hz tones as oddballs against repeated 1000-Hz tones. Participants' pupillary responses were recorded while they listened to the auditory oddball sequence. In Experiment 1, they were not involved in any task. Results show that pupils dilated to the noise oddballs for approximately 4 s, but no such PDR was found for the 2000-Hz tone oddballs. In Experiments 2, two types of visual oddballs were presented synchronously with the auditory oddballs. Participants discriminated the auditory or visual oddballs while trying to ignore stimuli from the other modality. The purpose of this manipulation was to direct attention to or away from the auditory sequence. In Experiment 3, the visual oddballs and the auditory oddballs were always presented asynchronously to prevent residuals of attention on to-be-ignored oddballs due to the concurrence with the attended oddballs. Results show that pupils dilated to both the noise and 2000-Hz tone oddballs in all conditions. Most importantly, PDRs to noise were larger than those to the 2000-Hz tone oddballs regardless of the attention condition in both experiments. The overall results suggest that the stimulus-dependent factor of the PDR appears to be independent of attention.