The prognostic value of B7-H6 protein expression in human oral squamous cell carcinoma
The prognostic value of B7-H6 protein expression in human oral squamous cell carcinoma
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B7-H6蛋白表达在人口腔鳞状细胞癌中的预后价值
DOI：
10.1111/jop.12586
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发表时间：
2017-10-01
影响因子：
3.3
通讯作者：
Chen, Qianming
中科院分区：
文献类型：
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作者：
Wang, Jiongke;Jin, Xin;Chen, Qianming
目的：探讨B7-H6蛋白在口腔鳞状细胞癌组织中的表达及其预后价值。材料与方法：50例口腔鳞状细胞癌、10例口腔白斑（OLK）和17例正常对照进行分析。免疫组化法检测B7-H6在口腔鳞状细胞癌、OLK和正常对照中的表达。结果：B7-H6蛋白在口腔鳞状细胞癌组织中的表达明显高于正常口腔黏膜。此外，B7-H6的表达与分化有显著关系，而与年龄、性别、肿瘤大小、淋巴转移、临床分期和复发无显著关系。此外，生存曲线显示B7-H6是口腔鳞状细胞癌患者总生存和无病生存的独立预后因素。通过COX比例风险回归模型进行多因素生存分析，发现B7-H6的复发、分化及表达与预后相关。最后，我们验证了B7-H6在口腔鳞状细胞癌中的预后价值。结论：B7-H6可能是口腔鳞状细胞癌新的预后指标。
Objectives: To investigate the expression and prognostic value of B7-H6 protein in oral squamous cell carcinoma tissues.Materials and Methods: A total of 50 oral squamous cell carcinoma samples, 10 oral leukoplakia (OLK) samples, and 17 normal controls were included in the analysis. The expression of B7-H6 in oral squamous cell carcinoma, OLK, and normal controls was evaluated by immunohistochemical assay.Results: The B7-H6 protein expression was significantly higher in oral squamous cell carcinoma tissues than that in normal oral mucosa. Furthermore, a significant relationship was found between the expression of B7-H6 and differentiation, but not with age, sex, tumor size, lymph metastasis, clinical stage, or recurrence. Further, the survival curves showed that B7-H6 was an independent prognostic factor of overall survival and disease-free survival in oral squamous cell carcinoma. Moreover, multivariate survival analysis by COX proportional hazard regression model revealed that the recurrence, differentiation, and expression of B7-H6 were related to the prognosis. Lastly, we verified the prognostic value of B7-H6 in oral squamous cell carcinoma.Conclusions: B7-H6 may represent a new prognostic marker for oral squamous cell carcinoma.