Comparison of Latino and non-Latino patients with Ewing sarcoma.
Comparison of Latino and non-Latino patients with Ewing sarcoma.
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拉丁裔和非拉丁裔尤文肉瘤患者的比较。
DOI：
10.1002/pbc.24745
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发表时间：
2014-02
影响因子：
3.2
通讯作者：
DuBois, Steven G.
中科院分区：
文献类型：
--
作者：
Sharib, Jeremy;Horvai, Andrew;Hazard, Florette K. Gray;Daldrup-Link, Heike;Goldsby, Robert;Marina, Neyssa;DuBois, Steven G.
尤文肉瘤(ES)是一种儿童和成人的骨和软组织恶性肿瘤。先前基于登记的研究表明，与非拉丁裔患者相比，患有ES的拉丁裔患者的预后较差，尽管这种差异的病因尚不能确定。为了探索可能导致这种差异的可能差异，我们进行了一项回溯性研究，比较拉美裔和非拉丁裔ES患者的临床特征、肿瘤特征、医疗保健途径和治疗结果。收集了1980至2010年间在两个学术医学中心接受治疗的218名ES患者的初步数据。分类数据比较采用Fisher精确检验；连续变量采用Wilcoxon秩和检验。生存估计采用Kaplan-Meier分析，比较采用对数等级检验。拉丁裔患者在更年轻的时候被诊断出来(p=0.014)。所有其他临床和组织学数据在两组之间是相似的，包括新辅助化疗的放射学和组织学反应。拉丁裔患者的社会经济地位较低(p=0.001)，不太可能有保险(p=0.001)，并且更有可能在出现症状时去急诊室(p=0.031)，而不是初级保健医生。拉丁裔和非拉丁裔患者的5年无事件生存率(EFS)和总生存率(OS)相似(EFS：60.5%对50.9%p=0.37；OS：77.6%对68.6%p=0.54)。患有ES的拉丁裔患者年龄较小，并有证据表明获得医疗保健的机会受到损害。拉丁裔和非拉丁裔患者对初始治疗的反应相似。
Ewing sarcoma (ES) is a malignancy of bone and soft tissue in children and adults. Previous registry-based studies indicate that Latino patients with ES have inferior outcomes compared to non-Latino patients, though an etiology for this difference could not be identified. To explore possible differences that might underlie this disparity, we conducted a retrospective study to compare clinical characteristics, tumor features, healthcare access, and treatment outcomes between Latino and non-Latino patients with ES. Primary data for 218 ES patients treated at two academic medical centers between 1980 and 2010 were collected. Categorical data were compared using Fisher exact tests; Wilcoxon rank-sum tests were used for continuous variables. Survival was estimated using Kaplan-Meier analysis and compared using log-rank testing. Latino patients were diagnosed at a younger age (p=0.014). All other clinical and histological data were similar between groups, including radiologic and histologic response to neoadjuvant chemotherapy. Latino patients had lower socioeconomic status (p=0.001), were less likely to have insurance (p=0.001), and were more likely to present to the emergency room at onset of symptoms (p= 0.031) rather than to primary care physicians. Five-year event free survival (EFS) and overall survival (OS) were similar between Latino and non-Latino patients (EFS: 60.5% vs. 50.9% p=0.37; OS: 77.6% vs. 68.6% p=0.54). Latino patients with ES present at a younger age, and have evidence of impaired access to healthcare. Response to initial therapy appears similar between Latino and non-Latino patients.
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影响因子：
6.4
作者：
Antonio Lopez-Guerrero, Jose;Machado, Isidro;Llombart-Bosch, Antonio
通讯作者：
Llombart-Bosch, Antonio
影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
影响因子：
6.2
作者：
Lee, Joe;Hoang, Bang H.;Zell, Jason A.
通讯作者：
Zell, Jason A.
影响因子：
45.3
作者：
Howell, Della L.;Ward, Kevin C.;Woods, William G.
通讯作者：
Woods, William G.
影响因子：
3.2
作者：
Bhatia, Smita
通讯作者：
Bhatia, Smita