Amniotic membrane transplantation with and without limbal stem cell transplantation in chemical eye injury
Amniotic membrane transplantation with and without limbal stem cell transplantation in chemical eye injury
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DOI：
10.3126/nepjoph.v7i1.13168
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发表时间：
2015-01-01
影响因子：
0.3
通讯作者：
Surin, L.
中科院分区：
文献类型：
--
作者：
Kafle, P. A.;Singh, S. K.;Surin, L.
眼睛的化学烧伤是视力残疾的重要原因之一。化学烧伤，特别是碱烧伤，可能导致严重的角膜缘干细胞缺乏。羊膜联合角膜缘移植是一种较好的眼表重建方法。案例：一名39岁的男性在化学损伤5个月后因发红、疼痛、恐惧症和视力逐渐丧失到Biratnagar眼科医院就诊。他的视力是在双眼中数靠近脸部的手指。右眼单纯羊膜移植，左眼角膜缘干细胞移植联合羊膜移植。右眼视力改善不多，而左眼显著改善至6/60。结论：角膜缘干细胞移植联合羊膜移植是一种较单纯羊膜移植更有效的治疗化学烧伤后角膜缘干细胞完全缺乏的方法。
Introduction: Chemical burns of the eyes are one of the important causes of visual disability. Chemical burns particularly alkali burn may lead to gross limbal stem cell deficiency. Amniotic membrane transplantation with limbal graft is a good method for ocular surface reconstruction. Case: A 39 years male presented to Biratnagar Eye Hospital aft er 5 months of chemical injury with redness, pain, photophobia and gradual loss of vision. His visual acuity was counting fingers close to face in both eyes. Amniotic membrane transplantation alone was done in right eye while in left eye limbal stem cell allograft was combined with amniotic membrane transplantation. There was not much visual improvement in right eye while left eye improved significantly to 6/60. Conclusion: Limbal stem cell graft with amniotic membrane transplantation can be an effective method of restoring vision and reducing symptoms rather than amniotic membrane transplantation alone in cases with total limbal stem cell deficiency following chemical burn.