Association of Circulating Retinol and Α-TOH Levels with Cognitive Function in Aging Subject with Type 2 Diabetes Mellitus
Association of Circulating Retinol and Α-TOH Levels with Cognitive Function in Aging Subject with Type 2 Diabetes Mellitus
复制标题
DOI：
10.1007/s12603-020-1328-1
复制
发表时间：
2020-01-22
影响因子：
5.8
通讯作者：
Yuan, L.
中科院分区：
文献类型：
--
作者：
Huang, X.;Guo, Y.;Yuan, L.
目的2型糖尿病（T2 DM）和痴呆患者存在维生素A（retinol）和维生素E（α-tocopherol，α-TOH）营养不良。然而，这些维生素如何影响T2 DM受试者的认知功能的报道很少。本研究的目的是确定循环视黄醇和α-TOH与老年T2 DM受试者认知的相关性。方法选择T2 DM患者448例，对照组448例，年龄55-75岁。收集了参与者的人口统计学特征。采用食物频率问卷（FFQ）法收集膳食摄入信息。为了评估认知状态，使用莫卡测试。在T2 DM和非T2 DM受试者之间比较循环视黄醇和α-TOH水平。在T2 DM受试者中分析了循环视黄醇和α-TOH水平与认知功能的相关性。探讨血清视黄醇和α-TOH水平对T2 DM患者MCI风险的影响。结果T2 DM-MCI组血清视黄醇水平明显低于T2 DM-nonMCI组（P < 0.01）。2型糖尿病患者血清视黄醇水平与认知功能呈正相关（P < 0.05）。2型糖尿病患者在视觉和执行、注意、语言、记忆和延迟回忆等方面的认知功能评分均高于对照组（P < 0.05）。结论T2 DM患者外周血中视黄醇水平降低可预测MCI的发生。我们的研究结果提供了建议，最佳的视黄醇营养状况可能有利于认知和降低MCI的风险，在老年人与T2 DM。
Objectives Malnutrition of vitamin A (retinol) and vitamin E (alpha-tocopherol, alpha-TOH) was observed in type 2 diabetes mellitus (T2DM) or dementia patients. However, how these vitamins affect cognitive function of subjects with T2DM was seldom reported. The objective of this study was to determine the association of circulating retinol and alpha-TOH with cognition in aging subjects with T2DM. Methods A total of 448 T2DM subjects and 448 age, gender and education matched control subjects (aged 55-75 years) were included in the study. Demographic characters of the participants were collected. Food frequency questionnaire (FFQ) method was used to collect dietary intake information. To assess the status of cognition, the MoCA test was used. Circulating retinol and alpha-TOH levels were compared between T2DM and non-T2DM subjects. Correlation of circulating retinol and alpha-TOH levels with cognitive function was analyzed in T2DM subjects. The effect of serum retinol and alpha-TOH levels on the risk of MCI in T2DM patients was explored. Results We found that T2DM-MCI subjects demonstrate lower serum retinol level than T2DM-nonMCI subjects (P < 0.01). Serum retinol level was positively correlated to cognitive function in T2DM subject (P < 0.05). T2DM subjects with higher circulating retinol level demonstrate higher cognitive scores in visual and executive, attention, language, memory and delayed recall domains (P < 0.05). Conclusion Diminished circulating retinol predicts an increased risk of MCI in T2DM patients. Our findings provide suggestions that optimal retinol nutritional status might benefit cognition and decrease the risk of MCI in aging subjects with T2DM.