Oral manifestations of HIV infection in relation to clinical and CD4 immunological status in northern and southern Thai patients
Oral manifestations of HIV infection in relation to clinical and CD4 immunological status in northern and southern Thai patients
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DOI：
10.1046/j.1601-0825.2003.00990.x
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发表时间：
2004-05-01
期刊：
影响因子：
3.8
通讯作者：
Robison, V
中科院分区：
文献类型：
--
作者：
Kerdpon, D;Pongsiriwet, S;Robison, V
目的：为了评估艾滋病毒感染者在泰国南部（一种新的艾滋病毒流行病）和泰国北方（一种成熟的流行病），艾滋病毒感染者的口腔表现的患病率和变化，以及与年龄，性别，危险行为，CD 4计数和药物used.SubjecTS和方法：共102和135名艾滋病毒感染者分别在北方和南方医院。口腔和血液学检查后进行的患者的社会人口访谈。从患者的病历中检索临床病史。结果：口腔念珠菌病（OC，55%），口腔毛状白斑（OHL，21%）和HIV相关的牙周病（14%）是泰国南部最常见的口腔病变。OHL（38%）、OC（25%）、HIV相关性牙周病（15%）是北方地区最常见的三种牙周病。发现任何口腔病变，OC，特别是伪膜型（PC）与两个部位的CD 4 < 200细胞mm（-3）之间存在显著相关性。在南方数据中，发现全身抗真菌治疗与OC（包括PC和念珠菌病（EC））呈负相关。在北方研究中心，OHL与男性性别呈正相关，与抗逆转录病毒治疗呈负相关。年轻的年龄，是一个当前的吸烟者与口腔病变在南方group.CONCLUSION：OC，特别是PC，可能是有用的免疫抑制的标志物，特别是在CD 4计数不能确定常规。抗真菌治疗是受益的受试者谁不能负担高效抗逆转录病毒治疗（HAART）。
OBJECTIVES: To assess prevalence and variations in the oral manifestations of HIV in HIV-infected subjects in southern Thailand (a new HIV epidemic) and northern Thailand (a mature epidemic), and the association with age, sex, risk behaviours, CD4 count and medication used.SUBJECTS AND METHODS: A total of 102 and 135 HIV-infected individuals were enrolled in northern and southern hospitals, respectively. Oral and haematological examination was performed after sociodemographic interview of the patients. Clinical history was retrieved from patients' medical records.RESULTS: Oral candidiasis (OC, 55%), oral hairy leucoplakia (OHL, 21%) and HIV-associated-periodontal disease (14%) were among the most common oral lesions in southern Thailand. OHL (38%), OC (25%), HIV-associated-periodontal disease (15%) were the three most common lesions in the north. A significant association was found between any oral lesion, OC, particularly the pseudomembranous type (PC), and CD4 < 200 cells mm(-3) at both sites. A negative relationship was found between systemic antifungal treatment and OC including PC and erythematous candidiasis (EC) in the southern data. OHL showed a positive relationship with male sex and a negative relationship with antiretroviral treatment in the northern site. Younger age and being a current smoker were positively associated with oral lesions in the southern group.CONCLUSION: OC, particularly PC, could be useful as a marker for immunosuppression, particularly where CD4 count cannot be determined routinely. Antifungal treatment is of benefit in the subjects who cannot afford highly active antiretroviral therapy (HAART).