Human brain: Reliability and reproducibility of pulsed arterial spin-labeling perfusion MR imaging
Human brain: Reliability and reproducibility of pulsed arterial spin-labeling perfusion MR imaging
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DOI：
10.1148/radiol.2343031499
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发表时间：
2005-03-01
期刊：
影响因子：
19.7
通讯作者：
Schuff, N
中科院分区：
文献类型：
--
作者：
Jahng, GH;Song, EM;Schuff, N
加州大学旧金山弗朗西斯科人类研究委员会批准了这项研究，所有志愿者都提供了书面知情同意书。本研究的目的是前瞻性地确定全球和区域的可靠性和（MR）成像方法，并确定受试者内变异的程度。和随机噪声限制了可靠性和再现性。13名健康志愿者在2小时内检查两次。在这项研究中比较的脉冲ASL方法的不同之处主要在于磁化传递和涡流效应。有两个主要结果：（a）脉冲ASL MR成像始终具有较高的测量可靠性（组内相关系数大于0.75）和再现性（变异系数小于8.5%），以及（B）随机噪声而不是受试者内变异性限制的可靠性和再现性。得出的结论是，低飞信号噪声比实质上限制了灌注测量的可靠性和再现性。(C)RSNA，2005年。
The Committee of Human Research of the University of California San Francisco approved this study, and all volunteers provided written informed consent. The goal of this study was to prospectively determine the global and regional reliability and (MR) imaging methods and to determine the extent to which within-subject variability. and random noise limit reliability and reproducibility. Thirteen healthy volunteers were examined twice within 2 hours. The pulsed ASL methods compared in this study differ mainly with regard to magnetization transfer and eddy current effects. There were two main results: (a) Pulsed ASL MR imaging consistently had high measurement I reliability (intraclass correlation coefficients greater than 0.75) and reproducibility (coefficients of variation less than 8.5%), and (b) random noise rather than within-subject variability limited reliability and reproducibility. It was concluded that low fly signal-to-noise ratios substantia limit the reliability and reproducibility of perfusion measurements. (C) RSNA, 2005.