Percutaneous cryoablation of small pulmonary malignant tumors under computed tomographic guidance with local anesthesia for nonsurgical candidates
Percutaneous cryoablation of small pulmonary malignant tumors under computed tomographic guidance with local anesthesia for nonsurgical candidates
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DOI：
10.1016/j.jtcvs.2005.12.051
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发表时间：
2006-05-01
影响因子：
6
通讯作者：
Kobayashi, K
中科院分区：
文献类型：
--
作者：
Kawamura, M;Izumi, Y;Kobayashi, K
目的：冷冻消融肺转移瘤是一种有效的非手术治疗方法。方法：对20例35个肿瘤患者(男12例，女8例；平均年龄57岁)行局部麻醉后行冷冻消融术。主要终点为冷冻消融的安全性和可行性，次要终点为肿瘤控制情况，每3个月进行一次动态CT扫描。结果：22例次冷冻消融术中发生气胸11例，咯血8例，膈神经麻痹1例。平均住院时间为2.6d。在9个月至28个月(中位数21个月)的随访期内，7例(35%)患者有7例(20%)肿瘤局部复发。根据Kaplan-Meier方法，1年生存率为89.4%。结论：经皮冷冻消融治疗转移性肺肿瘤是可行的，创伤小，局部控制满意。
Objective: Cryoablation of pulmonary metastases might be a useful therapy for nonsurgical candidates.Methods: The procedure was performed after achievement of local anesthesia for 35 tumors in 20 patients (12 male and 8 female patients; mean age, 57 years). The primary end point was the safety and feasibility of cryoablation, and the secondary end point was tumor control assessed by follow-up dynamic computed tomographic scanning performed every 3 months.Results: Of the 22 sessions of cryoablation, pneumothorax occurred in 11, hemoptysis occurred in 8, and there was 1 case of phrenic nerve palsy. The mean hospital stay was 2.6 days. There was local recurrence of 7 (20%) tumors in 7 (35%) patients during a 9- to 28-month (median, 21 months) follow-up period. One-year survival according to the Kaplan-Meier method was 89.4%.Conclusion: Percutaneous cryoablation therapy for metastatic lung tumors is feasible and minimally invasive, with satisfactory local control.