Effect of previous infection on antibody response of children to vaccination with capsular polysaccharide of Haemophilus influenzae Type b.
Effect of previous infection on antibody response of children to vaccination with capsular polysaccharide of Haemophilus influenzae Type b.
复制标题
既往感染对儿童b型流感嗜血杆菌荚膜多糖疫苗接种抗体反应的影响。
DOI：
10.1093/infdis/132.1.69
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
M. Melish
中科院分区：
文献类型：
--
作者：
C. Norden;R. Michaels;M. Melish
从B型流感嗜血杆菌引起的脑膜炎、眼眶蜂窝织炎或会厌炎中恢复的儿童，用该细菌衍生的荚膜多糖疫苗进行免疫;一些健康的兄弟姐妹和未患H.还接种了流感感染疫苗。对10例H.在此之前，只有一名流感脑膜炎患者对疫苗产生抗体反应。一个孩子先患H.流感性眼眶蜂窝织炎也没有反应。没有一个孩子有可检测的H。流感病毒多糖抗原在他们的血液中在免疫的时候。两个孩子谁有H。7例无H.流感感染对疫苗有免疫应答。2岁以下的8名接种者中有1名表现出反应，2年以上的12名接种者中有8名反应良好（P = 0.02）。所有4名2岁以上的无应答者均患有H;流感脑膜炎或蜂窝织炎。曾患H.流感脑膜炎对多糖疫苗的反应不如其他疫苗接种者;这种差异不能仅仅根据年龄来解释;
Children who had recovered from meningitis, orbital cellulitis, or epiglottitis caused by Haemophilus influenzae type b were immunized with capsular polysaccharide vaccine derived from that bacterium; some healthy siblings and adults who had not had H. influenzae infections were also vaccinated. Of 10 children who had had H. influenzae meningitis previously, only one had an antibody response to the vaccine. One child with prior H. influenzae orbital cellulitis also failed to respond. None of the children had detectable H. influenzae polysaccharide antigen in their bloodstream at the time of immunization. Two children who had had H. influenzae epiglottitis and six of seven controls without histories of H. influenzae infections responded immunologically to the vaccine. One of eight vaccinees under two years of age showed a response, and eight of 12 over two years responded well (P = 0.02). All four nonresponders over the age of two years had had H; influenzae meningitis or cellulitis. Children who had had H. influenzae meningitis responded less well to the polysaccharide vaccine than did other recipients of the vaccine; this difference could not be explained solely on the basis of age;