Effect on plasma free fatty acids on plasma glucagon and serum insulin concentrations.
Effect on plasma free fatty acids on plasma glucagon and serum insulin concentrations.
复制标题
血浆游离脂肪酸对血浆胰高血糖素和血清胰岛素浓度的影响。
DOI：
10.1016/0026-0495(68)90097-8
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发表时间：
1968
期刊：
影响因子：
--
通讯作者：
Barbara Barker
中科院分区：
文献类型：
--
作者：
Leonard L. Madison;Willis A. Seyffert;Roger H. Unger;Barbara Barker
急性升高血浆游离脂肪酸的水平，发现在长期饥饿期间通过输注甘油三酯乳剂加肝素在5只狗与血浆胰高血糖素下降40%，血清胰岛素增加33%。这种游离脂肪酸对胰高血糖素分泌的抑制性反馈和对胰岛素分泌的刺激性反馈很可能有助于从碳水化合物到脂肪代谢的平稳过渡，这是长期饥饿的特征，而没有进行性酮症酸中毒的危险。
The acute elevation of plasma free fatty acids to levels found during prolonged starvation by means of infusion of a triglyceride emulsion plus heparin in 5 dogs was associated with a 40 per cent decrease in plasma glucagon and a 33 per cent increase in serum insulin. This inhibitory feedback of free fatty acid on glucagon secretion and stimulatory feedback on insulin secretion very likely contribute to the smooth transition from carbohydrate to fat metabolism characteristic of prolonged starvation without the danger of progressive ketoacidosis.