COCAINE ADDICTION - PSYCHOLOGY AND NEUROPHYSIOLOGY
COCAINE ADDICTION - PSYCHOLOGY AND NEUROPHYSIOLOGY
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DOI：
10.1126/science.2011738
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发表时间：
1991-03-29
期刊：
影响因子：
56.9
通讯作者：
GAWIN, FH
中科院分区：
文献类型：
--
作者：
GAWIN, FH
可卡因在1980年被认为不会产生依赖性，但最近被宣布为全国最大的健康问题药物。 最近的临床和临床前研究表明，可卡因产生不同于其他主要滥用药物的独特滥用和戒断模式，并表明长期可卡因滥用在中枢神经系统的特定系统中产生神经生理学改变，这些系统调节体验快乐的能力。 在这些发现被认为是确定性的之前，有必要开发临床相关的研究模型，但是这些不断发展的想法已经导致了对可卡因滥用的有希望的实验性治疗的应用。
Cocaine was considered incapable of producing dependence in 1980 but was recently proclaimed the drug of greatest national health concern. Recent clinical and preclinical investigations demonstrate that cocaine produces unique abuse and withdrawal patterns that differ from those of other major abused drugs and suggest that long-term cocaine abuse produces neurophysiological alterations in specific systems in the central nervous system that regulate the capacity to experience pleasure. It will be necessary to develop clinically pertinent research models before these findings can be considered definitive, but these evolving ideas have already led to applications of promising experimental treatments for cocaine abuse.