The descriptive epidemiology of second primary breast cancer
The descriptive epidemiology of second primary breast cancer
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DOI：
10.1097/01.ede.0000072105.39021.6d
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发表时间：
2003-09-01
期刊：
影响因子：
5.4
通讯作者：
Thompson, WD
中科院分区：
文献类型：
--
作者：
Bernstein, JL;Lapinski, RH;Thompson, WD
背景：众所周知，原发性乳腺癌的发病率随着时间的推移而增加。相比之下，第二原发性乳腺癌的发病率在很大程度上没有文献记载。本研究描述了1973年至1998年美国305，533名确诊为乳腺癌的女性中第二原发性乳腺癌的流行病学。方法：我们根据诊断年份、人口统计学和肿瘤特征，比较了总的和第二原发性乳腺癌的年龄特异性发病率。总体而言，乳腺癌的年龄特异性发病率随着年龄和诊断年份的增加而增加，而第二原发性乳腺癌的发病率在年轻女性中达到峰值，并在1988年后下降。与已知的乳腺癌遗传易感性相一致，在每个年龄段，第二原发性乳腺癌的发生率都高于总体发生率;在20至29岁的女性中，第二原发性乳腺癌的发生率高出100倍以上。虽然非裔美国妇女的乳腺癌总体年龄特异性发病率低于白人，但第二次初选的发病率较高。第一原发性乳腺癌是小叶或髓质的妇女有更大的可能性发展为第二原发性乳腺癌，虽然，这些组织学types.Conclusions相对较少：第一和第二原发性乳腺癌的发病率的模式随时间和年龄的不同显着。
Background: It is well established that the incidence rates of first primary breast cancer have been increasing over time. In contrast, the incidence rates of second primary breast cancer are largely undocumented. This study describes the epidemiology of second primary breast cancer among a population-based cohort of 305,533 U.S. women diagnosed with breast cancer between 1973 and 1998.Methods: We compared age-specific incidence rates for overall and second primary breast cancer according to year of diagnosis and demographic and tumor characteristics.Results: Overall, age-specific rates of breast cancer increased with increasing age and year of diagnosis, whereas incidence of second primary breast cancer peaked among young women and declined after 1988. Consistent with what is known about genetic susceptibility to breast cancer, at every age the rate of second primaries was greater than the overall rate; among women age 20 to 29 years the rate of second primary was more than 100 times greater. Although overall age-specific rates of breast cancer for African-American women were lower than for whites, rates of second primaries were higher. Women with a first primary that was either lobular or medullary had a greater likelihood of developing a second primary, although, there were relatively few with these histologic types.Conclusions: The pattern of incidence rates for first and second primary breast cancer differ markedly over time and by age.