LYSOSOMAL CHITOBIASE (CTB) AND THE G-PROTEIN GAMMA(5) SUBUNIT (GNG5) GENES CO-LOCALIZE TO HUMAN-CHROMOSOME 1P22
LYSOSOMAL CHITOBIASE (CTB) AND THE G-PROTEIN GAMMA(5) SUBUNIT (GNG5) GENES CO-LOCALIZE TO HUMAN-CHROMOSOME 1P22
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DOI：
10.1159/000134059
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发表时间：
1995-01-01
期刊：
影响因子：
--
通讯作者：
ARONSON, NN
中科院分区：
文献类型：
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作者：
AHMAD, W;LI, S;ARONSON, NN
先前分离的人胎盘cDNA克隆代表由两种基因编码的特异性RNA序列的融合：溶酶体壳聚糖酶（CTB）和G-蛋白γ（5）亚基（GNG 5，Fisher和Aronson，1992 a，1992 b）。通过体细胞杂交的PCR分析，这两个基因现在都被定位到1 p，并通过荧光原位杂交（FISH）使用含有壳二酰化酶和γ（5）基因的YAC克隆进一步细化到1 p22。
Previously isolated human placental cDNA clones represent a fusion of specific RNA sequences encoded by two genes: lysosomal chitobiase (CTB) and G-protein gamma(5) subunit (GNG5, Fisher and Aronson, 1992a, 1992b). Both genes have now been mapped to 1p by PCR analysis of somatic cell hybrids and further refined to 1p22 by fluorescence in situ hybridization (FISH) using a YAC clone that contains both the chitobiase and gamma(5) genes.