Short term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS)
Short term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS)
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DOI：
10.1136/thorax.58.8.686
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发表时间：
2003-08-01
期刊：
影响因子：
10
通讯作者：
Li, PCK
中科院分区：
文献类型：
--
作者：
Chan, JWM;Ng, CK;Li, PCK
背景资料：方法：2003年3月至6月初，香港地区确诊SARS患者1700余例。方法：2003年3月至5月31日，香港地区大型区域医院伊利沙伯医院收治确诊SARS患者115例，其中100例已出院或死亡。入院后对患者进行前瞻性研究，以评估其短期结局和与不良结局相关的危险因素，定义为死亡或需要机械通气。结果：在撰写本文时，18例患者死亡，粗死亡率为15.7%，21天死亡率为10%（标准误3%）。39名患者（34%）入住重症监护室，其中30名（26%）需要机械通气。多变量分析显示，年龄超过60岁（风险比（HR）3.5，95% CI 1.2至10.2; p=0.02），存在糖尿病或心脏病（HR 9.1，95% CI 2.8至29。1; p
Background: Severe acute respiratory syndrome (SARS) was diagnosed in Hong Kong in over 1700 patients between March and early June 2003.Methods: 115 patients diagnosed with SARS were admitted to Queen Elizabeth Hospital, a large regional hospital in Hong Kong, from March 2003, of whom 100 were either discharged or were dead at 3 1 May. The patients were prospectively studied after admission to assess their short term outcomes and the risk factors associated with adverse outcomes, defined as death or the need for mechanical ventilationResults: At the time of writing 18 patients had died, with a crude mortality rate of 15.7% and a 21 day mortality of 10% (standard error 3%). Thirty nine patients (34%) were admitted to the intensive care unit, 30 of whom (26%) required mechanical ventilation. Multivariate analysis showed that age above 60 (hazards ratio (HR) 3.5, 95% Cl 1.2 to 10.2; p=0.02), presence of diabetes mellitus or heart disease (HR 9.1, 95% Cl 2.8 to 29. 1; p