Proposed pathogenic mechanism for the diarrhea associated with human intestinal spirochetes.
Proposed pathogenic mechanism for the diarrhea associated with human intestinal spirochetes.
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提出了与人类肠道螺旋体相关的腹泻的致病机制。
DOI：
10.1093/ajcp/86.5.679
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发表时间：
1986
影响因子：
3.5
通讯作者：
C. Hawkey
中科院分区：
文献类型：
--
作者：
F. Rodgers;C. Rodgers;A. Shelton;C. Hawkey
在一例持续性腹泻患者的粪便和直肠活检中发现了类似阿尔博氏短螺旋体的螺旋体。虽然这种微生物在细菌培养基上不能生长，但它被发现附着在直肠管腔上皮细胞的表面。细胞微绒毛明显变钝和破坏。这些诱导的病理性细胞表面变化，以及直肠细胞中细胞内细菌的存在，提示了与这种疾病相关的持续腹泻的致病机制。甲硝唑治疗后螺旋体病和临床症状均消失。
Spirochetes resembling Brachyspira aalborgi were found in the feces and rectal biopsies of a patient with persistent diarrhea. Although the organism failed to grow on bacteriologic media, it was found attached to the surfaces of the epithelial cells on the rectal lumen. Blunting and destruction of the cellular microvilli was evident. These induced pathologic cell surface changes, together with the presence of intracellular bacteria in the cells of the rectal colon, suggest a pathogenic mechanism for the persistent diarrhea often associated with this condition. Both the spirochetosis and clinical symptoms disappeared on treatment with metronidazole.