Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis
Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis
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DOI：
10.1086/426139
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发表时间：
2005-01-01
影响因子：
11.8
通讯作者：
Lalvani, A
中科院分区：
文献类型：
--
作者：
Wilkinson, KA;Wilkinson, RJ;Lalvani, A
血液中早期分泌性抗原靶-6（ESAT- 6）特异性、分泌干扰素- g的T细胞的存在准确地标志着结核感染。在10例结核病患者的结核性胸腔积液中，这些细胞相对于其在外周血中的水平平均浓缩15倍（标准差，+/- 6倍）（P = 0.014），并显示出快速效应功能。在8例非结核性胸膜疾病的对照患者中，这些细胞均不存在。ESAT- 6特异性T细胞向发炎的结核组织的募集证明了它们在体内的功能，并提出了诊断结核性胸膜炎的新方法。
Presence of early secretory antigenic target- 6 ( ESAT- 6) - specific, interferon- g - secreting T cells in blood accurately marks tuberculosis infection. In tuberculous pleural effusions from 10 patients with tuberculosis, these cells were concentrated a mean of 15- fold ( standard deviation, +/- 6- fold), relative to their level in peripheral blood (P = .014), and displayed rapid effector function. Such cells were absent in 8 control patients with nontuberculous pleural disease. The recruitment of ESAT- 6 - specific T cells to inflamed tuberculous tissue demonstrates their function in vivo and suggests a novel way to diagnose tuberculous pleuritis.