The synthesis of an exhaustively stereodiversified library of cis-1,5 enediols by silyl-tethered ring-closing metathesis.
The synthesis of an exhaustively stereodiversified library of cis-1,5 enediols by silyl-tethered ring-closing metathesis.
复制标题
通过甲硅烷基束缚的闭环复分解合成彻底立体多样化的 cis-1,5 烯二醇文库。
作者：
B. Harrison;G. Verdine
[反应：见正文]本报告描述了顺式-1，5-englutamine模块1的所有16种立体异构体的平行合成。化合物1通过硅系闭环复分解反应由化合物2衍生而来。这种立体异构化配体的文库提供了一种独特的方法来发现配体，该方法采用构象空间的穷举搜索。
[reaction: see text] This report describes the parallel synthesis of all 16 stereoisomers of the cis-1,5 enediol module 1. Compounds 1 derive from 2 by silicon-tethered ring-closing metathesis. Such libraries of stereodiversified ligands provide a unique approach to ligand discovery that employs exhaustive searching of conformational space.