Prospective study of dietary fat and risk of cataract extraction among US women.
Prospective study of dietary fat and risk of cataract extraction among US women.
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DOI：
10.1093/aje/kwi118
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发表时间：
2005-05
影响因子：
5
通讯作者：
Minyi Lu;E. Cho;A. Taylor;S. Hankinson;W. Willett;P. Jacques
中科院分区：
文献类型：
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作者：
Minyi Lu;E. Cho;A. Taylor;S. Hankinson;W. Willett;P. Jacques
作者从护士健康研究中前瞻性地研究了成年女性饮食脂肪摄入量与白内障摘除之间的关系。从1984年到2000年，共有71,083名妇女接受了长达16年的前瞻性跟踪调查。通过重复的食物频率问卷评估膳食脂肪。白内障摘除事件由两年一次的问卷调查确定。脂肪摄入量最高者与最低五分之一者经多因素调整后的相对危险度为1.10(95%可信区间：0.99，1.22；p(趋势)=0.01)。与长链omega-3脂肪酸最低五分之一的女性相比，长链omega-3脂肪酸最高五分之一的女性摘除白内障的风险低12%(相对风险=0.88，95%CI：0.79，0.98；p(趋势)=0.02)。鱼的总摄入量与白内障呈负相关(摄入量：相对危险度=0.89，95%CI：0.81，0.98；P(趋势)=0.01)。作者的发现表明，摄入更多的长链omega-3脂肪酸(二十碳五烯酸和二十二碳六烯酸)和食用鱼类可能会适度降低患白内障的风险。
The authors examined prospectively the association between dietary fat intake and cataract extraction in adult women from the Nurses' Health Study. A total of 71,083 women were followed prospectively for up to 16 years between 1984 and 2000. Dietary fat was assessed by repeated food frequency questionnaires. Incident cases of cataract extraction were determined by a biennial questionnaire. The multivariate-adjusted relative risk for the highest compared with the lowest quintile of total fat intake was 1.10 (95% confidence interval (CI): 0.99, 1.22; p(trend) = 0.01). Women in the highest quintile of long-chain omega-3 fatty acid had a 12% lower risk of cataract extraction compared with those in the lowest quintile (relative risk = 0.88, 95% CI: 0.79, 0.98; p(trend) = 0.02). Total fish intake was inversely associated with cataract (for intake of > or = 3/week vs. <1/month: relative risk = 0.89, 95% CI: 0.81, 0.98; p(trend) = 0.01). The authors' findings suggest that higher intake of long-chain omega-3 fatty acid (eicosapentaenoic acid and docosahexaenoic acid) and consumption of fish may modestly reduce the risk of cataract.