Effects of low doses of casein hydrolysate on post-challenge glucose and insulin levels
Effects of low doses of casein hydrolysate on post-challenge glucose and insulin levels
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DOI：
10.1016/j.ejim.2010.12.015
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发表时间：
2011-06-01
影响因子：
8
通讯作者：
Smit, J. W. A.
中科院分区：
文献类型：
--
作者：
Jonker, J. T.;Wijngaarden, M. A.;Smit, J. W. A.
背景：摄入高剂量酪蛋白水解物刺激健康受试者和2型糖尿病患者的胰岛素分泌。低剂量的影响尚未研究。本研究的目的是评估低剂量的酪蛋白水解物对2型糖尿病患者口服葡萄糖耐量试验的葡萄糖和胰岛素反应的影响。方法：在这项随机、安慰剂对照、双盲研究中，13例2型糖尿病患者，（年龄：在口服0（对照），结果：12克酪蛋白水解物，而不是6克，在激发后升高胰岛素水平和降低葡萄糖水平。这些随时间的变化不足以影响葡萄糖和胰岛素曲线下总面积。结论：摄入6克酪蛋白水解物不影响葡萄糖或胰岛素反应。在2型糖尿病患者中，摄入12 g酪蛋白水解物对攻毒后胰岛素和葡萄糖水平有较小的积极影响。(C)2011年欧洲内科联合会。Elsevier B.V.出版，保留所有权利。
Background: Ingestion of high doses of casein hydrolysate stimulates insulin secretion in healthy subjects and patients with type 2 diabetes. The effects of low doses have not been studied. The aim of this study was to assess the effect of lower doses of a casein hydrolysate on the glucose and insulin responses to an oral glucose tolerance test in patients with type 2 diabetes.Methods: In this randomized, placebo-controlled, double-blind study, thirteen patients with type 2 diabetes (age: 58 +/- 1 years) were studied.Glucose, insulin and C-peptide responses were determined after the oral administration of 0 (control), 6 or 12 g protein hydrolysate in combination with 50 g carbohydrate.Results: Twelve grams of casein hydrolysate, but not 6 g, elevated insulin levels and decreased glucose levels post-challenge. These changes over time were not large enough to also affect the total area under the curve of glucose and insulin. C-peptide levels did not change after both treatments.Conclusion: Ingestion of six grams of casein hydrolysate did not affect glucose or insulin responses. Intake of 12 g of casein hydrolysate has a small positive effect on post-challenge insulin and glucose levels in patients with type 2 diabetes. (C) 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.