HCK can serve as novel prognostic biomarker and therapeutic target for Breast Cancer patients.
HCK can serve as novel prognostic biomarker and therapeutic target for Breast Cancer patients.
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HCK 可作为乳腺癌患者的新型预后生物标志物和治疗靶点
DOI：
10.7150/ijms.43161
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发表时间：
2020
影响因子：
3.6
通讯作者：
Liu C
中科院分区：
文献类型：
--
作者：
Zhu X;Zhang Y;Bai Y;Gu X;Chen G;Sun L;Wang Y;Qiao X;Ma Q;Zhu T;Bu J;Xue J;Liu C
HCK表达在乳腺癌患者预后中的作用尚不清楚。因此，本研究旨在探讨HCK在乳腺癌中表达的临床意义。我们使用Oncomine、GEPIA、UALCAN和cBioPortal数据库评估了乳腺癌中HCK的表达和遗传变异。采用免疫组化法检测HCK在乳腺癌组织、非癌组织和转移癌组织中的表达。因此，我们评估了HCK表达对无病生存期（DFS）和总生存期（OS）的影响。最后，利用STRING、Coexpedia和TISIDB数据库对HCK的分子功能和调控途径进行了分析。我们发现，乳腺癌组织中有更多的HCK mRNA转录比非癌组织。HCK阳性患者的DFS和OS明显缩短，癌组织中HCK的表达率高于非癌组织。STRING数据库、FunRich软件和TISIDB数据库的这些结果表明，HCK通过多种信号通路参与介导多个生物学过程，包括免疫应答调节信号通路、细胞生长和维持，所述多个信号通路包括上皮向间充质转化、PI 3 K/AKT信号通路和粘着斑。因此，HCK可能是乳腺癌发生发展中的一个癌基因，因此可能成为乳腺癌的一个新的生物标志物和治疗靶点。
The role of HCK expression in the prognosis of breast cancer patients is unclear. Thus, this study aimed to explore the clinical implications of HCK expression in breast cancer. We assessed HCK expression and genetic variations in breast cancer using Oncomine, GEPIA, UALCAN, and cBioPortal databases. Then, immunochemistry was used to analyze HCK expression in breast cancer specimens, non-cancer tissues and metastatic cancer tissues. Consequently, we evaluated the effect of HCK expression on survival outcomes set as disease-free survival (DFS) and overall survival (OS). Finally, STRING, Coexpedia, and TISIDB database were explored to identify the molecular functions and regulation pathways of HCK. We found that breast cancer tissues have more HCK mRNA transcripts than non-cancer tissues. Patients with HCK expression had significantly shorter DFS and OS. The ratio of HCK expression was higher in cancer tissues than in non-cancer tissues. These results from STRING database, FunRich software, and TISIDB database showed that HCK was involved in mediating multiple biological processes including immune response-regulating signaling pathway, cell growth and maintenance through multiple signaling pathways including epithelial to mesenchymal transition, PI3K/AKT signaling pathway, and focal adhesion. Overall, HCK may be an oncogene in the development of breast cancer and thus may as a novel biomarker and therapeutic target for breast cancer.
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DOI：
10.1084/jem.20020873
发表时间：
2002-09-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ernst M;Inglese M;Scholz GM;Harder KW;Clay FJ;Bozinovski S;Waring P;Darwiche R;Kay T;Sly P;Collins R;Turner D;Hibbs ML;Anderson GP;Dunn AR
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DOI：
10.1158/1078-0432.ccr-10-2081
发表时间：
2011-04-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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作者：
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通讯作者：
Sood AK
影响因子：
64.5
作者：
Acharyya S;Oskarsson T;Vanharanta S;Malladi S;Kim J;Morris PG;Manova-Todorova K;Leversha M;Hogg N;Seshan VE;Norton L;Brogi E;Massagué J
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Massagué J
影响因子：
50.3
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Poh AR;Love CG;Masson F;Preaudet A;Tsui C;Whitehead L;Monard S;Khakham Y;Burstroem L;Lessene G;Sieber O;Lowell C;Putoczki TL;O'Donoghue RJJ;Ernst M
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Ernst M
DOI：
10.6004/jnccn.2019.0009
发表时间：
2019-02-01
影响因子：
13.4
作者：
Goetz, Matthew P.;Gradishar, William J.;Kumar, Rashmi
通讯作者：
Kumar, Rashmi