Plasma and interstitial volumes in essential hypertension: relationship to blood pressure.
Plasma and interstitial volumes in essential hypertension: relationship to blood pressure.
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原发性高血压的血浆和间质体积：与血压的关系。
DOI：
10.1042/cs0610287
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发表时间：
1981
期刊：
影响因子：
6
通讯作者：
A. Smith
中科院分区：
文献类型：
--
作者：
R. Bing;A. Smith
1. 对患有无并发症且未经治疗的原发性高血压的男性同时测量了血浆和间质液体积。 2. 原发性高血压患者的血浆容量（伊文思蓝）减少，且与血压成反比。 3. 来自溴间隙和血浆容量的间质液容量在原发性高血压中也减少，并且与血压成反比。血浆和间质液体积平均减少 6-7%。 4.没有证据表明原发性高血压会导致容量扩张，并且血浆和间质液容量之间的关系得以保留。血浆和间质液量的收缩最有可能反映继发于肾灌注压升高的尿钠排泄和利尿，并且钠潴留不太可能是原发性高血压的主要事件。
1. Plasma and interstitial fluid volumes have been measured simultaneously in men with uncomplicated and untreated essential hypertension. 2. Plasma volume (Evans blue) was reduced in essential hypertension and correlated inversely with blood pressure. 3. Interstitial fluid volume, derived from bromine space and plasma volume, was also reduced in essential hypertension and correlated inversely with blood pressure. The mean reduction in both plasma and interstitial fluid volumes was 6-7%. 4. There is no evidence for volume expansion in essential hypertension and the relationship between plasma and interstitial fluid volumes is preserved. The contraction of plasma and interstitial fluid volumes is most likely to reflect a natriuresis and diuresis secondary to the raised renal perfusion pressure, and sodium retention is unlikely to be a primary event in essential hypertension.