Preliminary report of improved sleep quality in patients with dry eye disease after initiation of topical therapy.
Preliminary report of improved sleep quality in patients with dry eye disease after initiation of topical therapy.
复制标题
局部疗法开始后干眼症患者睡眠质量改善的初步报告。
DOI：
10.2147/ndt.s94648
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发表时间：
2016
影响因子：
3.2
通讯作者：
Tsubota K
中科院分区：
文献类型：
--
作者：
Ayaki M;Toda I;Tachi N;Negishi K;Tsubota K
干眼症（DED）可能与睡眠和情绪障碍有关。本研究使用基于眼表的调查评估了DED患者在局部眼药水治疗前后的睡眠质量。还评估了睡眠和眼科服务在帮助眼科疾病患者解决睡眠问题方面的有效性。71名连续的DED患者在不同地点的8家普通眼科诊所接受了一份包含匹兹堡睡眠质量指数和医院焦虑和抑郁量表的问卷调查。畏光症和时辰型（早晨/晚上）也进行了评估，从既定的问卷调查（国家眼科研究所视觉功能问卷-25和早晨/晚上问卷）的两个代表性的问题。在初次评估后3-10个月通过面谈或邮件进行随访评估。在两个眼科诊所建立了睡眠服务，以识别与睡眠和情绪障碍相关的可能的眼部疾病;它包括问卷调查、睡眠日记、活动图、医学访谈、视野测试、视网膜神经节细胞层厚度测量和DED检查。与确诊的DED患者相比，新诊断的DED患者在DED治疗后的睡眠改善更大。匹兹堡睡眠质量指数的改善是显著的（P<0.05），并且与新患者的医院焦虑和抑郁量表的改善密切相关（P<0.05），但与已确诊的DED患者无关。10名眼科诊所的患者访问了睡眠服务，其中9人患有DED。他们成功地接受了眼药水和睡眠服务，其中包括蓝光屏蔽眼镜和可穿戴蓝光治疗灯根据他们的问题。在有或没有睡眠服务的局部治疗后，DED患者的睡眠质量得到改善。专注于睡眠障碍的精神病治疗可能对DED患者有益。
Dry eye disease (DED) is potentially associated with sleep and mood disorders. This study evaluated sleep quality in patients with DED using a questionnaire-based survey before and after topical eyedrop treatment. The effectiveness of sleep and ophthalmic services in assisting with sleep problems in patients with eye disease was also assessed. Seventy-one consecutive patients with DED visiting eight general eye clinics in various locations answered a questionnaire containing the Pittsburgh Sleep Quality Index and Hospital Anxiety and Depression Scale. Photophobia and chronotype (morningness/eveningness) were also evaluated with two representative questions from established questionnaires (National Eye Institute Visual Function Questionnaire-25 and Morningness/Eveningness questionnaire). Follow-up evaluation was conducted by interview or mail 3–10 months after the initial evaluation. A sleep service was established in two eye clinics to identify possible ocular diseases related to sleep and mood disorders; it comprised a questionnaire, sleep diary, actigram, medical interviews, visual field testing, retinal ganglion cell layer thickness measurement, and DED examination. Patients with newly diagnosed DED exhibited a greater improvement in sleep after DED treatment compared with patients with established DED. Improvement in Pittsburgh Sleep Quality Index was significant (P<0.05) and strongly correlated with improvement in Hospital Anxiety and Depression Scale (P<0.05) for new patients, but not for patients with established DED. Ten eye clinic patients visited the sleep service and nine of them had DED. They were successfully treated with eyedrops and sleep services, which included blue-light-shield eyewear and wearable blue-light therapy lamps according to their problem. Sleep quality improved in patients with DED after topical treatment with or without the sleep service. Psychiatric treatment focusing on sleep disorders could be beneficial for patients with DED.