Cancer treatment-induced alterations in muscular fitness and quality of life: the role of exercise training
Cancer treatment-induced alterations in muscular fitness and quality of life: the role of exercise training
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DOI：
10.1093/annonc/mdm364
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发表时间：
2007-12-01
影响因子：
50.5
通讯作者：
Hayward, R.
中科院分区：
文献类型：
--
作者：
Schneider, C. M.;Hsieh, C. C.;Hayward, R.
背景：癌症幸存者经历肌肉无力和活动能力降低，从而影响生活质量。这项研究利用适度的处方运动来改善癌症患者的上半身和下半身肌肉健康、灵活性、抑郁和生活质量。135名乳腺癌和前列腺癌幸存者接受了癌症和病史筛查和医学检查，以及肌肉力量评估（握力测力计）和耐力（卧推、侧向下拉、腿部推举、肩部推举和蜷缩紧缩测试）、柔韧性（改良坐位和前伸）、抑郁（Beck抑郁量表）和生活质量（生活质量指数）。运动评估后，癌症幸存者在治疗期间或治疗后根据评估结果和健康状况进行6个月的抗阻运动训练。治疗后的癌症幸存者表现出显著的（P = 0.006）上肢肌肉耐力改善（+46.8%），下身肌肉耐力（+67.1%），核心肌肉耐力（+32.5%）和灵活性（+6.2%），抑郁（-25.6%）和总生活质量（+7.2%）也随之改善（P = 0.013）。治疗期间的癌症幸存者表现出显著的（P = 0.012）上肢肌肉耐力改善（+79.1%）和下半身肌肉耐力（+49.7%），同时保持核心耐力和灵活性，并进行改进（P = 0.022）（-43.0%）和生活质量（+11.5%）。中等强度的个体化处方运动是一种安全有效的手段，以增强肌肉功能和改善癌症幸存者的生活质量。
Background: Cancer survivors experience muscular weakness and reduced mobility, thereby compromising quality of life. This investigation utilized moderate prescriptive exercise to improve upper- and lower-body muscular fitness, flexibility, depression and quality of life in cancer patients.Patients and methods: One hundred and thirty-five breast and prostate cancer survivors received cancer and medical history screening and a medical examination, as well as assessments of muscular strength (handgrip dynamometer) and endurance (bench press, lateral pull-down, leg press, shoulder press and curl-up crunch test), flexibility (Modified Sit and Reach), depression (Beck Depression Inventory) and quality of life (Quality of Life Index). Following the exercise assessments, cancer survivors trained in resistance exercise for 6 months during treatment or following treatment based on their results from the assessments and health status.Results: Cancer survivors following treatment showed significant (P = 0.006) improvements in upper-body muscular endurance (+46.8%), lower-body muscular endurance (+67.1%), core muscular endurance (+32.5%) and flexibility (+6.2%), with concomitant improvements (P = 0.013) in depression (-25.6%) and total quality of life (+7.2%). Cancer survivors during treatment showed significant (P = 0.012) improvements in upper-body muscular endurance (+79.1%) and lower-body muscular endurance (+49.7%) while maintaining core endurance and flexibility in conjunction with improvements (P = 0.022) in depression (-43.0%) and quality of life (+11.5%).Conclusions: Moderate- intensity individualized prescriptive exercise is a safe and efficacious means to augment muscular function and improve the quality of life of cancer survivors.