Exercise-induced changes in immune function: effects of zinc supplementation.
Exercise-induced changes in immune function: effects of zinc supplementation.
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运动引起的免疫功能变化：补锌的影响。
DOI：
10.1152/jappl.1994.76.6.2298
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发表时间：
1994
影响因子：
3.3
通讯作者：
P. Deuster
中科院分区：
文献类型：
--
作者：
Anita Singh;M. Failla;P. Deuster
为了研究补充锌对运动引起的免疫功能变化的影响，5名男性跑步者被随机分配到一个双盲交叉设计中，每天两次服用补充剂（S; 25 mg锌和1.5 mg铜）或安慰剂（P），持续6天。在每个阶段的第4天早晨，服用S或P后1小时，受试者在跑步机上以最大摄氧量的70-75%跑步，直到耗尽（约2小时）。在运行前（Pre）、运行后即刻（Post）以及运行后1天（Rec 1）和2天（Rec 2）采集血样。经丝裂原处理的单核细胞培养物的[3 H]胸苷掺入显著降低P运动后中性粒细胞呼吸爆发活性增强，而S运动后中性粒细胞呼吸爆发活性无明显变化（P> 0.05）（P：前12.0 +/- 1.1 vs.后17.6 +/- 2.3 nmol O2-/10（6）细胞; S：前11.7 +/- 0.3 vs.后12.1 +/- 1.2 nmol O2-/10（6）细胞）。因此，补充锌阻断了运动引起的活性氧增加。锌的这种抗氧化作用是否会使暴露于慢性身体压力的个体受益仍有待确定。
To examine the effect of zinc (Zn) supplementation on exercise-induced changes in immune function, five male runners were randomly assigned in a double-blind crossover design to take a supplement (S; 25 mg of Zn and 1.5 mg of copper) or placebo (P) twice daily for 6 days. On morning 4 of each phase, 1 h after taking S or P, subjects ran on a treadmill at 70-75% of maximal oxygen uptake until exhaustion (approximately 2 h). Blood samples were obtained before (Pre), immediately after (Post), and 1 (Rec1) and 2 (Rec2) days after the run. [3H]thymidine incorporation by mitogen-treated mononuclear cell cultures was significantly lower (P < 0.05) Post than Pre, Rec1, or Rec2 for both S and P. Respiratory burst activity of isolated neutrophils was enhanced after exercise with P but not with S (P: Pre 12.0 +/- 1.1 vs. Post 17.6 +/- 2.3 nmol O2-/10(6) cells; S: Pre 11.7 +/- 0.3 vs. Post 12.1 +/- 1.2 nmol O2-/10(6) cells). Thus supplemental Zn blocked the exercise-induced increase in reactive oxygen species. Whether this antioxidant effect of Zn will benefit individuals exposed to chronic physical stress remains to be determined.