Applications of LC-MS in the study of the uptake, distribution, metabolism and excretion of bioactive polyphenols from dietary supplements
Applications of LC-MS in the study of the uptake, distribution, metabolism and excretion of bioactive polyphenols from dietary supplements
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DOI：
10.1016/j.lfs.2005.12.002
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发表时间：
2006-03-27
期刊：
影响因子：
6.1
通讯作者：
Moore, DR
中科院分区：
文献类型：
--
作者：
Barnes, S;Prasain, JK;Moore, DR
对体液中的生物活性成分及其代谢物进行特异性和定量分析对于评估膳食补充剂和精神活性药物制剂中化合物组之间的相互作用至关重要。反相 LC 分离与串联质谱法相结合提供了必要的特异性和灵敏度。本文描述了这些方法在血清、尿液和房水中异黄酮、丹酚酸 A、辛弗林异构体及其代谢物分析中的应用。 (c) 2006 Elsevier Inc. 保留所有权利。
Specific and quantitative analyses of the bioactive components and their metabolites in body fluids are essential to assess the interaction between groups of compounds in dietary supplements and preparations of psychoactives. Reverse-phase LC separations combined with tandem mass spectrometry provide the necessary specificity and sensitivity. In this paper, applications of these methods are described for the analysis of isoflavones, salvinorin A, synephrine isomers and their metabolites in serum, urine and aqueous humor. (c) 2006 Elsevier Inc. All rights reserved.