Absorbed radiation dose to humans from technetium-99m-teboroxime.
Absorbed radiation dose to humans from technetium-99m-teboroxime.
复制标题
人体从锝-99m-替硼肟吸收的辐射剂量。
作者：
R. Narra;T. Feld;A. Nunn
在9名正常志愿者中获得的组织分布数据被用来估计静脉注射99 mTc-替硼肟（Teboroxime，Tebortec）后对人体的辐射剂量。使用定量SPECT测量器官摄取占注射剂量的百分比。采用非线性回归分析软件对器官时间-活动数据进行分析。在考虑放射性核素的物理衰变后，通过计算相应曲线下的面积来确定这些器官中的累积活度。使用MIRDOSE 2程序估计单个器官的吸收剂量。胆囊和上大肠（ULI）是靶器官，将分别接受26.5和33.2 μ Gy/MBq（98和123 mrad/mCi）99 mTc-替硼肟，假设胆囊每6小时排空一次，胆囊排空间隔越短，胆囊剂量越小;间隔3、4和5小时，对胆囊的相应剂量为18.2、21.0和23.7 μ Gy/MBq（67.4、77.8和87.9 mrad/mCi）99 mTc-替硼肟。然而，ULI的剂量几乎保持恒定在123 mrad/mCi，并将成为限制因素。
Tissue distribution data obtained in nine normal volunteers were used to estimate the radiation dose to humans after intravenous administration of 99mTc-teboroxime (Cardiotec). Organ uptake as percent of injected dose was measured using quantitative SPECT. Non-linear regression analysis was performed on the organ time-activity data using SYSTAT software. Cumulative activities in these organs were determined by calculating the area under the respective curves after accounting for the physical decay of the radionuclide. The absorbed dose to individual organs was estimated using the MIRDOSE 2 program. The gallbladder and the upper large intestine (ULI) are the target organs and will receive respectively 26.5 and 33.2 muGy/MBq (98 and 123 mrad/mCi) 99mTc-teboroxime under the assumption that the gallbladder empties every 6 hr. The dose to the gallbladder decreases at shorter emptying intervals; with intervals of 3, 4, and 5 hr, the respective doses to the gallbladder are 18.2, 21.0 and 23.7 muGy/MBq (67.4, 77.8, and 87.9 mrad/mCi) 99mTc-teboroxime. However, the dose to ULI remains almost constant at 123 mrad/mCi and will be the limiting factor.
Technetium-99m-SQ30217 的心肌清除动力学：局部心肌血流的标志物。
DOI：
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发表时间：
1990
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
Stewart,RE;Schwaiger,M;Hutchins,GD;Chiao,PC;Gallagher,KP;Nguyen,N;Petry,NA;Rogers,WL
通讯作者：
Rogers,WL