An Image-based Approach for 3D Left Atrium Functional Measurements.

An Image-based Approach for 3D Left Atrium Functional Measurements.
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DOI:
10.22489/cinc.2020.459
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发表时间:
2020-09
期刊:
Computing in cardiology
影响因子:
--
通讯作者:
Elhabian S
Elhabian S
中科院分区:
其他
文献类型:
--
作者:
Morris A;Kholmovski E;Marrouche N;Cates J;Elhabian S

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人们对心房颤动 (AF) 患者左心房 (LA) 功能的评估越来越感兴趣。现有的 LA 功能测量方法仅量化来自 LA 的单平面或双平面 CINE-MRI 扫描的功能参数的有限子集。在这里,我们提出了一种基于图像的方法,用于对整个 LA 的功能进行 3D 综合评估。 4D LA 图像是根据覆盖整个 LA 的一系列 CINE 图像堆栈重建的,薄片之间的间隙很小或没有间隙。高分辨率磁共振血管造影 (MRA) 的分割通过覆盖心动周期的成对可变形配准进行配准和传播。计算每个时间点的体积、LA 射血分数和表面应变,并注册到 52 名患者扫描中每一次的晚期钆增强 (LGE) 扫描。 LGE 和应变之间的相关系数为 -0.11,表明纤维化组织与弹性降低相关。
There is growing interest in the assessment of function of the left atrium (LA) in patients with atrial fibrillation (AF). Existing methods of LA functional measurement only quantify a limited subset of the functional parameters from a single or biplane CINE-MRI scan through the LA. Here, we propose an image-based method for comprehensive evaluation of the function of the entire LA in 3D. 4D LA images were reconstructed from a series of CINE image stack covering the whole LA with small or no gap between thin slices. A segmentation from a high-resolution Magnetic Resonance Angiography (MRA) was registered and propagated through pairwise deformable registrations covering the cardiac cycle. Volume, LA ejection fraction and surface strain were computed for each timepoint and registered to Late Gadolinium Enhancement (LGE) scans for each of 52 patient scans. A correlation coefficient of −0.11 was calculated between LGE and strain, indicating that fibrotic tissue correlates with reduced elasticity.
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