Vasopressin opposes locomotor stimulation by ethanol, cocaine and amphetamine in mice
Vasopressin opposes locomotor stimulation by ethanol, cocaine and amphetamine in mice
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DOI：
10.1016/s0014-2999(98)00465-8
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发表时间：
1998-08-14
影响因子：
5
通讯作者：
Lê, DA
中科院分区：
文献类型：
--
作者：
Chiu, J;Kalant, H;Lê, DA
在DBA/2N小鼠上，观察了精氨酸(8)-加压素对乙醇、可卡因和苯丙胺诱发的运动刺激的影响。在给予乙醇、可卡因或安非他明后，通过光电池束阻断45min的时间来测量运动活动。每只小鼠皮下注射2(而不是1)微克/只的加压素。运动活动减少。小剂量加压素不能改变腹腔注射对运动活动的刺激作用。注射剂量为1.5或2克/公斤的乙醇。大剂量的加压素以一种明显的相加方式降低了两种剂量的乙醇所诱导的运动活动。15 mg/kg和20 mg/kg剂量的可卡因对大鼠的运动活动有强烈的刺激作用，但这种刺激可被1 mg/kg的加压素完全拮抗。同样，加压素可阻断苯丙胺(5 mg/kg)引起的运动刺激。这些发现提出了一种可能性，即后叶加压素的作用因药物诱导的活动刺激中多巴胺能参与的程度和性质而不同。对于可卡因或安非他明等主要通过中脑边缘多巴胺能系统刺激运动活动的药物，加压素可以完全拮抗这种刺激。对于乙醇，它通过对其他一些神经递质和多巴胺的作用来刺激运动活动，后叶加压素治疗只是以相加的方式减少了对运动活动的刺激。这些结果表明，加压素和多巴胺之间存在密切的相互作用。(C)1998 Elsevier Science B.V.保留所有权利。
The effects of arginine(8)-vasopressin on the stimulation of locomotor activity induced by ethanol, cocaine and amphetamine were examined in DBA/2N mice. Locomotor activity was measured by photocell beam interruption for a period of 45 min following ethanol, cocaine or amphetamine administration. Pretreatment with vasopressin alone in a dose of 2 (but not 1) mu g/mouse s.c. reduced locomotor activity. The low dose of vasopressin did not modify the stimulation of locomotor activity induced by i.p. administration of ethanol in doses of either 1.5 or 2 g/kg. The high dose of vasopressin reduced locomotor activity induced by both doses of ethanol, in an apparently additive manner. Cocaine in doses of 15 and 20 mg/kg strongly stimulated locomotor activity, but this stimulation was completely antagonized by pretreatment with 1 mu g of vasopressin. Similarly, the stimulation of locomotor activity induced by amphetamine (5 mg/kg) was also blocked by pretreatment with vasopressin. These findings raise the possibility that the effect of vasopressin varies with the extent and nature of dopaminergic involvement in the drug-induced stimulation of activity. For drugs like cocaine or amphetamine which stimulate locomotor activity primarily through the mesolimbic dopaminergic system, vasopressin can completely antagonize the stimulation. For ethanol, which stimulates locomotor activity through action on a number of other neurotransmitters as well as dopamine, vasopressin treatment only reduces its stimulation of locomotor activity in an additive manner. These results suggest a close interaction between vasopressin and dopamine action. (C) 1998 Elsevier Science B.V. All rights reserved.